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Platelet transfusio...
Platelet transfusions in adult ICU patients with thrombocytopenia : A sub-study of the PLOT-ICU inception cohort study
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- Anthon, Carl Thomas (författare)
- Copenhagen University Hospital
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- Pène, Frédéric (författare)
- Université Paris Cité
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- Perner, Anders (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Azoulay, Elie (författare)
- Université Paris Cité
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- Puxty, Kathryn (författare)
- Glasgow Royal Infirmary
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- Van De Louw, Andry (författare)
- Pennsylvania State University College of Medicine
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- Chawla, Sanjay (författare)
- Weill Cornell Medical College,Memorial Sloan-Kettering Cancer Center
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- Castro, Pedro (författare)
- University of Barcelona
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- Povoa, Pedro (författare)
- Centro Hospitalar de Lisboa Ocidental (CHLO),NOVA University Lisbon,Odense University Hospital
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- Coelho, Luis (författare)
- Centro Hospitalar de Lisboa Ocidental (CHLO),NOVA University Lisbon
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- Metaxa, Victoria (författare)
- King's College Hospital
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- Kochanek, Matthias (författare)
- University of Cologne
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- Liebregts, Tobias (författare)
- University Hospital Essen
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- Kander, Thomas (författare)
- Lund University,Lunds universitet,Klinisk forskning inom anestesi och intensivvårdsmedicin,Forskargrupper vid Lunds universitet,Clinical Research in Anaesthesia and Intensive Care Medicine,Lund University Research Groups,Skåne University Hospital
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- Sivula, Mirka (författare)
- University of Helsinki,Helsinki University Central Hospital
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- Andreasen, Jo Bønding (författare)
- Aalborg University Hospital
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- Nielsen, Lene Bjerregaard (författare)
- Odense University Hospital
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- Hvas, Christine Lodberg (författare)
- Aarhus University Hospital
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- Dufranc, Etienne (författare)
- Assistance Publique des Hôpitaux de Paris
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- Canet, Emmanuel (författare)
- University of Nantes
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- Wright, Christopher John (författare)
- Queen Elizabeth University Hospital
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- Schmidt, Julien (författare)
- Assistance Publique des Hôpitaux de Paris
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- Uhel, Fabrice (författare)
- Université Paris Cité
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- Missri, Louai (författare)
- Paris-Sorbonne University
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- Krag, Mette (författare)
- University of Copenhagen,Holbæk Hospital
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- Cos Badia, Elisabet (författare)
- Hospital General de Granollers
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- Díaz-Lagares, Cándido (författare)
- Vall d'Hebron University Hospital
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- Menat, Sophie (författare)
- Paris-Sorbonne University
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- Voiriot, Guillaume (författare)
- Paris-Sorbonne University
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- Erikstrup Clausen, Niels (författare)
- Bispebjerg Hospital
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- Lorentzen, Kristian (författare)
- Copenhagen University Hospital
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- Kvåle, Reidar (författare)
- University of Bergen,Haukeland University Hospital
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- Barratt-Due, Andreas (författare)
- Oslo university hospital
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- Hildebrandt, Thomas (författare)
- Zealand University Hospital
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- Holten, Aleksander Rygh (författare)
- Oslo university hospital,University of Oslo
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- Strand, Kristian (författare)
- Stavanger University Hospital
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- Bestle, Morten Heiberg (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Klepstad, Pål (författare)
- St. Olav’s University Hospital,Norwegian University of Science and Technology
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- Vimpere, Damien (författare)
- Université Paris Cité
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- Paulino, Carolina (författare)
- Hospital da Luz
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- Lueck, Catherina (författare)
- Hannover Medical School
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- Juhl, Christian Svendsen (författare)
- Copenhagen University Hospital
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- Costa, Carolina (författare)
- Hospital Professor Doutor Fernando Fonseca
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- Bådstøløkken, Per Martin (författare)
- Akershus University Hospital
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- Lêdo, Lia Susana Aires (författare)
- Hospital de Egas Moniz
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- Møller, Morten Hylander (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Russell, Lene (författare)
- Université Paris Cité,University of Copenhagen,Copenhagen University Hospital
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(creator_code:org_t)
- Engelska.
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Ingår i: Acta Anaesthesiologica Scandinavica. - 0001-5172.
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Platelet transfusions are frequently used in the intensive care unit (ICU), but current practices including used product types, volumes, doses and effects are unknown.STUDY DESIGN AND METHODS: Sub-study of the inception cohort study 'Thrombocytopenia and Platelet Transfusions in the ICU (PLOT-ICU)', including acutely admitted, adult ICU patients with thrombocytopenia (platelet count <150 × 10 9/L). The primary outcome was the number of patients receiving platelet transfusion in ICU by product type. Secondary outcomes included platelet transfusion details, platelet increments, bleeding, other transfusions and mortality. RESULTS: Amongst 504 patients with thrombocytopenia from 43 hospitals in 10 countries in Europe and the United States, 20.8% received 565 platelet transfusions; 61.0% received pooled products, 21.9% received apheresis products and 17.1% received both with a median of 2 (interquartile range 1-4) days from admission to first transfusion. The median volume per transfusion was 253 mL (180-308 mL) and pooled products accounted for 59.1% of transfusions, however, this varied across countries. Most centres (73.8%) used fixed dosing (medians ranging from 2.0 to 3.5 × 10 11 platelets/transfusion) whilst some (mainly in France) used weight-based dosing (ranging from 0.5 to 0.7 × 10 11 platelets per 10 kg body weight). The median platelet count increment for a single prophylactic platelet transfusion was 2 (-1 to 8) × 10 9/L. Outcomes of patients with thrombocytopenia who did and did not receive platelet transfusions varied. CONCLUSIONS: Among acutely admitted, adult ICU patients with thrombocytopenia, 20.8% received platelet transfusions in ICU of whom most received pooled products, but considerable variation was observed in product type, volumes and doses across countries. Prophylactic platelet transfusions were associated with limited increases in platelet counts.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Anthon, Carl Tho ...
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Pène, Frédéric
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Perner, Anders
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Azoulay, Elie
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Puxty, Kathryn
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Van De Louw, And ...
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visa fler...
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Chawla, Sanjay
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Castro, Pedro
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Povoa, Pedro
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Coelho, Luis
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Metaxa, Victoria
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Kochanek, Matthi ...
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Liebregts, Tobia ...
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Kander, Thomas
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Sivula, Mirka
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Andreasen, Jo Bø ...
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Nielsen, Lene Bj ...
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Hvas, Christine ...
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Dufranc, Etienne
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Canet, Emmanuel
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Wright, Christop ...
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Schmidt, Julien
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Uhel, Fabrice
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Missri, Louai
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Krag, Mette
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Cos Badia, Elisa ...
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Díaz-Lagares, Cá ...
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Menat, Sophie
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Voiriot, Guillau ...
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Erikstrup Clause ...
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Lorentzen, Krist ...
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Kvåle, Reidar
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Barratt-Due, And ...
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Hildebrandt, Tho ...
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Holten, Aleksand ...
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Strand, Kristian
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Bestle, Morten H ...
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Klepstad, Pål
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Vimpere, Damien
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Paulino, Carolin ...
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Lueck, Catherina
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Juhl, Christian ...
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Costa, Carolina
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Bådstøløkken, Pe ...
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Lêdo, Lia Susana ...
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Møller, Morten H ...
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Russell, Lene
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Anestesi och int ...
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Acta Anaesthesio ...
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