Changes in insulin-like growth factor 1 receptor density after transient cerebral ischemia in the rat : Lack of protection against ischemic brain damage following injection of insulin-like growth factor 1

Binding of 125I-insulin-like growth factor-1 (125I-IGF-1) to rat brain slices was studied after 15 min of two-vessel occlusion ischemia and 1 h to 4 days of recirculation. Ligand binding in the hippocampus increased at 6 h post ischemia in the CA1 and CA3 regions and the dentate gyrus, suggesting that the IGF-1 receptors were up-regulated, while no change was seen in neocortex and striatum. Intracerebroventricular injections of IGF-1 (2 μg) prior to and after transient cerebral ischemia did not reduce neuronal damage. The increased up-regulation on IGF-1 receptors and the absence of neuroprotection by IGF-1 suggest that the intracellular signal transduction chain activated by the IGF-1 receptor may be interrupted.

Wieloch, T.Lund University,Lunds universitet,Laboratory for Experimental Brain Research,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)efor-twi (författare)
Skåne University HospitalLund University (creator_code:org_t)

Ingår i:Journal of Cerebral Blood Flow and Metabolism: SAGE Publications13:5, s. 895-8980271-678X1559-7016

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