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Update on the patho...
Update on the pathophysiology of transfusion-related acute lung injury
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- Zeeuw van der Laan, Eveline A.N. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,University of Amsterdam
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- van der Velden, Saskia (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,University of Amsterdam
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- Porcelijn, Leendert (author)
- Sanquin Diagnostic Services
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- Semple, John W. (author)
- Lund University,Lunds universitet,Trombocyt immunologi,Forskargrupper vid Lunds universitet,Platelet Immunology,Lund University Research Groups
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- van der Schoot, C. Ellen (author)
- University of Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Kapur, Rick (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,University of Amsterdam
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(creator_code:org_t)
- 2020
- 2020
- English 6 s.
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In: Current Opinion in Hematology. - 1531-7048. ; 27:6, s. 386-391
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http://dx.doi.org/10...
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Abstract
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- PURPOSE OF REVIEW: The aim of this study was to discuss recent advances regarding the pathogenesis of transfusion-related acute lung injury (TRALI), which highlight the pathogenic role of macrophages. RECENT FINDINGS: TRALI remains a leading cause of transfusion-related fatalities, despite the success of the mitigation strategy, and therapeutic approaches are unavailable. Neutrophils (PMNs) are recognized pathogenic cells in TRALI. Macrophages have previously also been suggested to be pathogenic in mice via binding of C5a to their C5a-receptor, producing reactive oxygen species (ROS), which damages the pulmonary endothelium. Recent work has further highlighted the role of macrophages in the TRALI-pathogenesis. It has been shown that the protein osteopontin (OPN) released by macrophages is critical for pulmonary PMN recruitment in mice suffering from TRALI and that targeting OPN prevents the occurrence of TRALI. Another recent study demonstrated the importance of M1-polarized alveolar macrophages in murine TRALI induction by showing that α1-antitrypsin (AAT) overexpression prevented TRALI in mice through decreasing the polarization of alveolar macrophages towards the M1 phenotype. SUMMARY: Apart from PMNs, macrophages also appear to be important in the pathogenesis of TRALI. Targeting the pathogenic functions of macrophages may be a promising therapeutic strategy to explore in TRALI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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