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Spi-C, a novel Ets ...
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Bemark, MatsLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Lärare vid läkarprogrammet,Avdelningen för läkarprogrammets kursadministration,Utbildningsenheten,Kansli M,Medicinska fakulteten,Immunology,Lund University Research Groups,Teachers at the Medical Programme,Division of Course Administration for the Medical Programme,The Education Office,Faculty Office - BMC,Faculty of Medicine
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Spi-C, a novel Ets protein that is temporally regulated during B lymphocyte development
- Artikel/kapitelEngelska1999
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LIBRIS-ID:oai:lup.lub.lu.se:2d9fa33e-fc76-4261-afb1-672263537e0d
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https://lup.lub.lu.se/record/2d9fa33e-fc76-4261-afb1-672263537e0dURI
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https://doi.org/10.1074/jbc.274.15.10259DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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A novel Ets protein was isolated by yeast one-hybrid screening of a cDNA library made from lipopolysaccharide-stimulated mouse splenic B cells, using the SP6 κ promoter κY element as a bait. The novel Ets protein was most closely related to PU.1 and Spi-B within the DNA binding Ets domain and was therefore named Spi-C. However, Spi-C may represent a novel subgroup within the Ets protein family, as it differed significantly from Spi-B and PU.1 within helix 1 of the Ets domain. Spi-C was encoded by a single-copy gene that was mapped to chromosome 10, region C. Spi-C interacted with DNA similarly to PU.1 as judged by methylation interference, band-shift and site selection analysis, and activated transcription of a κY element reporter gene upon co-transfection of HeLa cells. Spi-C RNA was expressed in mature B lymphocytes and at lower levels in macrophages. Furthermore, pre-B cell and plasma cell lines were Spi-C-negative, suggesting that Spi-C might be a regulatory molecule during a specific phase of B lymphoid development.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mårtensson, AnnicaLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)extLU-1016
(författare)
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Liberg, DavidLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)med-dlr
(författare)
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Leanderson, TomasLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)immu-tle
(författare)
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ImmunologiForskargrupper vid Lunds universitet
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Sammanhörande titlar
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Ingår i:Journal of Biological Chemistry: Elsevier BV274:15, s. 10259-102670021-9258
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