Sökning: WFRF:(Daha Mohamed R) >
Age and sex-associa...
Age and sex-associated changes of complement activity and complement levels in a healthy caucasian population
-
- Da Costa, Mariana Gaya (författare)
- University of Groningen,University Medical Center Groningen
-
- Poppelaars, Felix (författare)
- University Medical Center Groningen,Martini Hospital, Groningen,University of Groningen
-
- Van Kooten, Cees (författare)
- Leiden University,Leiden University Medical Centre
-
visa fler...
-
- Mollnes, Tom E. (författare)
- Oslo university hospital,Norwegian University of Science and Technology,UiT The Arctic University of Norway, Tromsø,Nordland Hospital Bodø,University of Oslo
-
- Tedesco, Francesco (författare)
- Istituto Auxologico Italiano
-
- Würzner, Reinhard (författare)
- Medical University of Innsbruck
-
- Trouw, Leendert A. (författare)
- Leiden University Medical Centre
-
- Truedsson, Lennart (författare)
- Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine
-
- Daha, Mohamed R. (författare)
- University of Groningen,Leiden University Medical Centre,Leiden University,University Medical Center Groningen
-
- Roos, Anja (författare)
- St. Antonius Hospital
-
- Seelen, Marc A. (författare)
- University of Groningen,University Medical Center Groningen
-
visa färre...
-
(creator_code:org_t)
- 2018-11-20
- 2018
- Engelska.
-
Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 9:NOV
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://www.frontier...
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Introduction: The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to first analyze this system under different physiological conditions. The aim of the present study was therefore to investigate the inter-individual variation in complement activity and the influences of age and sex. Methods: Complement levels and functional activity were determined in 120 healthy volunteers, 60 women, 60 men, age range 20-69 year. Serum functional activity of the classical pathway (CP), lectin pathway activated by mannan (MBL-LP) and alternative pathway (AP) was measured in sera, using deposition of C5b-9 as readout. In addition, levels of C1q, MBL, MASP-1, MASP-2, ficolin-2, ficolin-3, C2, C4, C3, C5, C6, C7, C8, C9, factor B, factor D, properdin, C1-inhibitor and C4b-binding protein, were determined. Age- and sex-related differences were evaluated. Results: Significantly lower AP activity was found in females compared to males. Further analysis of the AP revealed lower C3 and properdin levels in females, while factor D concentrations were higher. MBL-LP activity was not influenced by sex, but MBL and ficolin-3 levels were significantly lower in females compared to males. There were no significant differences in CP activity or CP components between females and males, nevertheless females had significantly lower levels of the terminal components. The CP and AP activity was significantly higher in the elderly, in contrast to MBL-LP activity. Moreover, C1-inhibitor, C5, C8, and C9 increased with age in contrast to a decrease of factor D and C3 levels. In-depth analysis of the functional activity assays revealed that MBL-LP activity was predominantly dependent on MBL and MASP-2 concentration, whereas CP activity relied on C2, C1-inhibitor and C5 levels. AP activity was strongly and directly associated with levels of C3, factor B and C5. Conclusion: This study demonstrated significant sex and age-related differences in complement levels and functionality in the healthy population. Therefore, age and sex analysis should be taken into consideration when discussing complement-related pathologies and subsequent complement-targeted therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Complement
- Gender
- Health
- Innate imunity
- Sex and age
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Da Costa, Marian ...
-
Poppelaars, Feli ...
-
Van Kooten, Cees
-
Mollnes, Tom E.
-
Tedesco, Frances ...
-
Würzner, Reinhar ...
-
visa fler...
-
Trouw, Leendert ...
-
Truedsson, Lenna ...
-
Daha, Mohamed R.
-
Roos, Anja
-
Seelen, Marc A.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Immunologi inom ...
- Artiklar i publikationen
-
Frontiers in Imm ...
- Av lärosätet
-
Lunds universitet