Dyskinesias following neural transplantation in Parkinson's disease.

• Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

Parkinson Disease : therapy

Parkinson Disease : radionuclide imaging

Neurons : transplantation

Middle Age

Mesencephalon : transplantation

Mesencephalon : embryology

Mesencephalon : cytology

Hyperkinesis : etiology

Hyperkinesis : diagnosis

Human

Dystonia : etiology

Dystonia : diagnosis

Dyskinesias : etiology

Dyskinesias : diagnosis

Disease Progression

Cultured

Cells

Brain Tissue Transplantation : adverse effects

Cell Division : physiology

Postoperative Complications : diagnosis

Postoperative Complications : etiology

Putamen : physiopathology

Putamen : radionuclide imaging

Retrospective Studies

Support

Non-U.S. Gov't

Time Factors

Publication and Content Type

art (subject category)

ref (subject category)