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High levels of (un)...
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Meeuwsen, John A.L.University Medical Center Utrecht
(författare)
High levels of (un)switched memory B cells are associated with better outcome in patients with advanced atherosclerotic disease
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:2f2fd028-3667-437b-bfee-da05774b6797
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https://lup.lub.lu.se/record/2f2fd028-3667-437b-bfee-da05774b6797URI
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https://doi.org/10.1161/JAHA.117.005747DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Background--Atherosclerosis is an inflammatory lipid disorder and the main underlying pathology of acute ischemic events. Despite a vast amount of data from murine atherosclerosis models, evidence of B-cell involvement in human atherosclerotic disease is limited. We therefore investigated the association of circulating B-cell subtypes with the occurrence of secondary cardiovascular events in advanced atherosclerotic disease. Methods and Results--This cohort study consists of 168 patients who were included in the Athero-Express biobank between 2009 and 2011. Before surgery, peripheral blood mononuclear cells were isolated and stored in liquid nitrogen. After gentle thawing of the peripheral blood mononuclear cells, different B-cell subtypes including naïve, (un)switched memory, and CD27+CD43+ B1-like B cells, were analyzed by flow cytometry. Univariable and multivariable Cox proportional hazard models were used to analyze associations between B-cell subtypes, circulating antibodies and secondary cardiovascular manifestations during the 3-year follow-up period. Mean age was 70.1±9.6 years, males represented 62.8% of the population, and 54 patients had secondary manifestations during follow-up. High numbers of unswitched memory cells were protective against secondary outcome (hazard ratio, 0.30 [95% CI, 0.13-0.69]; P < 0.01). Similar results were obtained for the switched memory cells that also showed to be protective against secondary outcome (hazard ratio, 0.33 [95% CI, 0.14-0.77]; P = 0.01). Conclusions--A high number of (un)switched memory B cells is associated with better outcome following carotid artery endarterectomy. These findings suggest a potential role for B-cell subsets in prediction and prevention of secondary cardiovascular events in patients with atherosclerosis.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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van Duijvenvoorde, AmerikUniversity Medical Center Utrecht
(författare)
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Gohar, AishaUniversity Medical Center Utrecht
(författare)
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Kozma, Maria O.Medical University of Vienna
(författare)
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van de Weg, Sander M.University Medical Center Utrecht
(författare)
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Gijsberts, Crystel MUniversity Medical Center Utrecht
(författare)
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Haitjema, SaskiaUniversity Medical Center Utrecht
(författare)
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Björkbacka, HarryLund University,Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Forskargrupper vid Lunds universitet,Cardiovascular Research - Cellular Metabolism and Inflammation,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-hbj
(författare)
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Fredrikson, Gunilla N.Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-gno
(författare)
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de Borst, Gert J.University Medical Center Utrecht
(författare)
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den Ruijter, Hester MUniversity Medical Center Utrecht
(författare)
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Pasterkamp, GerardUniversity Medical Center Utrecht
(författare)
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Binder, Christoph J.Medical University of Vienna
(författare)
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Hoefer, Imo EUniversity Medical Center Utrecht
(författare)
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de Jager, Saskia C AUniversity Medical Center Utrecht
(författare)
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University Medical Center UtrechtMedical University of Vienna
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of the American Heart Association6:92047-9980
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Meeuwsen, John A ...
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van Duijvenvoord ...
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Gohar, Aisha
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Kozma, Maria O.
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van de Weg, Sand ...
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Haitjema, Saskia
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Björkbacka, Harr ...
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Fredrikson, Guni ...
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de Borst, Gert J ...
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den Ruijter, Hes ...
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Pasterkamp, Gera ...
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Binder, Christop ...
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Hoefer, Imo E
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de Jager, Saskia ...
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