Sökning: WFRF:(Lövgren J.)
> (1995-1999) >
Chemical characteri...
Chemical characterization of the predominant proteins secreted by mouse seminal vesicles
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- Lundwall, Åke (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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Peter, A. (författare)
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Lövgren, J. (författare)
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visa fler...
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- Lilja, Hans (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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Malm, J. (författare)
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visa färre...
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(creator_code:org_t)
- 1997
- 1997
- Engelska.
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Ingår i: Eur J Biochem. ; 249:1, s. 39-44
- Relaterad länk:
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http://www.ncbi.nlm.... (free)
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Mouse seminal vesicles secrete four major protein components with estimated molecular masses of 95, 38, 17, and 16 kDa. Amino acid sequencing revealed that the 95-kDa component represents a protein with an unknown structure, while the 38-kDa component was identified as semenoclotin, the 17-kDa component as seminal-vesicle-secreted protein IV, and the 16-kDa component as seminal-vesicle-secreted protein V. Semenoclotin and the 95-kDa component were readily cross-linked by transglutaminase, suggesting that the two proteins are involved in the formation of the mouse copulatory plug. Treatment of mouse seminal vesicle fluid with human prostate-specific antigen rapidly degraded semenoclotin, indicating a structural resemblance of this protein to human semenogelins, despite the vast difference in primary structure. As previously reported for other seminal-vesicle-secreted proteins, the semenoclotin transcripts are shown to be under androgen control.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Nyckelord
- RNA
- Proteins/*chemistry/genetics/*secretion
- Post-Translational
- Protein Processing
- Molecular Weight
- Inbred BALB C
- Mice
- Male
- Humans
- Gonadal Steroid Hormones/chemistry/genetics
- Cross-Linking Reagents
- Amino Acid Sequence
- Animals
- Messenger/genetics/metabolism
- Research Support
- Non-U.S. Gov't
- *Seminal Vesicle Secretory Proteins
- Seminal Vesicles/chemistry/drug effects/*secretion
- Testosterone/pharmacology
- Transglutaminases
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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