Sökning: WFRF:(Junker K) >
Increased synovial ...
Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis
-
- Nielsen, M. A. (författare)
- Aarhus University,Aarhus University Hospital
-
- Køster, D. (författare)
- Aarhus University
-
- Greisen, S. (författare)
- Aarhus University,Aarhus University Hospital
-
visa fler...
-
- Troldborg, A. (författare)
- Aarhus University,Aarhus University Hospital
-
- Stengaard-Pedersen, K. (författare)
- Aarhus University Hospital
-
- Junker, P. (författare)
- Odense University Hospital
-
- Hørslev-Petersen, K. (författare)
- University of Southern Denmark
-
Hetland, M. L. (författare)
-
Østergaard, M. (författare)
-
- Hvid, M. (författare)
- Aarhus University
-
- Leffler, H. (författare)
- Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine
-
- Kragstrup, T. W. (författare)
- Aarhus University Hospital,Aarhus University
-
- Deleuran, B. (författare)
- Aarhus University,Aarhus University Hospital
-
visa färre...
-
(creator_code:org_t)
- 2022-01-13
- 2023
- Engelska.
-
Ingår i: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 0300-9742 .- 1502-7732. ; 52:1, s. 33-41
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: Galectin-3 (Gal-3) has been suggested as a proinflammatory mediator in rheumatoid arthritis (RA). We aimed to study clinical and pathogenic aspects of Gal-3 in RA. Method: Plasma samples from healthy controls (n = 48) and patients with newly diagnosed, early RA were assayed for soluble Gal-3. In patients with chronic RA (n = 18), Gal-3 was measured in both plasma and synovial fluid. Synovial fluid mononuclear cells were used to purify fibroblast-like synoviocytes (FLSs) and osteoclasts. Monocultures of FLSs and autologous co-cultures of FLSs and peripheral blood mononuclear cells were established and co-incubated with a Gal-3 inhibitor. Results: Patients with early and chronic RA had persistently increased plasma levels of Gal-3 compared with controls. However, changes in plasma Gal-3 at the level of individuals were associated with long-term disease activity. In seropositive early RA patients, all patients with decreasing plasma Gal-3 from 0 to 3 months had low disease activity after 2 years (p < 0.05). Gal-3 levels in synovial fluid were markedly elevated. In vitro, co-incubation with a Gal-3 inhibitor (GB1107, 10 µM) led to a significant reduction in both interleukin-1β and tumour necrosis factor-α secretion from FLS monocultures (both p < 0.05) and decreased monocyte-derived osteoclastogenesis compared with controls (both p < 0.05). Conclusions: Our findings underscore the role of Gal-3 regarding disease activity and tissue destruction in RA. An initial decrease in plasma Gal-3 levels predicted decreased long-term disease activity. Correspondingly, a Gal-3 inhibitor decreased the activity of inflammatory FLSs and osteoclastogenesis in patients with RA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Nielsen, M. A.
-
Køster, D.
-
Greisen, S.
-
Troldborg, A.
-
Stengaard-Peders ...
-
Junker, P.
-
visa fler...
-
Hørslev-Petersen ...
-
Hetland, M. L.
-
Østergaard, M.
-
Hvid, M.
-
Leffler, H.
-
Kragstrup, T. W.
-
Deleuran, B.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reumatologi och ...
- Artiklar i publikationen
-
Scandinavian Jou ...
- Av lärosätet
-
Lunds universitet