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Intravenous zoledro...
Intravenous zoledronic acid in postmenopausal women with low bone mineral density
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Reid, IR (author)
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Brown, JP (author)
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Burckhardt, P (author)
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Horowitz, Z (author)
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Richardson, P (author)
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Trechsel, U (author)
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Widmer, A (author)
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Devogelaer, J (author)
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Kaufman, J (author)
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Jaeger, P (author)
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Body, J (author)
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Meunier, PJ (author)
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- Samsioe, Göran (author)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: New England Journal of Medicine. - 0028-4793. ; 346:9, s. 653-661
- Related links:
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http://content.nejm....
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https://lup.lub.lu.s...
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Abstract
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- Background: Bisphosphonates are effective agents for the management of osteoporosis. Their low bioavailability and low potency necessitate frequent administration on an empty stomach, which may reduce compliance. Gastrointestinal intolerance limits maximal dosing. Although intermittent intravenous treatments have been used, the optimal doses and dosing interval have not been systematically explored. Methods: We studied the effects of five regimens of zoledronic acid, the most potent bisphosphonate, on bone turnover and density in 351 postmenopausal women with low bone mineral density in a one-year, randomized, double-blind, placebo-controlled trial. Women received placebo or intravenous zoledronic acid in doses of 0.25 mg, 0.5 mg, or 1 mg at three-month intervals. In addition, one group received a total annual dose of 4 mg as a single dose, and another received two doses of 2 mg each, six months apart. Lumbar-spine bone mineral density was the primary end point. Results: There were similar increases in bone mineral density in all the zoledronic acid groups to values for the spine that were 4.3 to 5.1 percent higher than those in the placebo group (P<0.001) and values for the femoral neck that were 3.1 to 3.5 percent higher than those in the placebo group (P<0.001). Biochemical markers of bone resorption were significantly suppressed throughout the study in all zoledronic acid groups. Myalgia and pyrexia occurred more commonly in the zoledronic acid groups, but treatment-related dropout rates were similar to that in the placebo group. Conclusions: Zoledronic acid infusions given at intervals of up to one year produce effects on bone turnover and bone density as great as those achieved with daily oral dosing with bisphosphonates with proven efficacy against fractures, suggesting that an annual infusion of zoledronic acid might be an effective treatment for postmenopausal osteoporosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Reid, IR
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Brown, JP
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Burckhardt, P
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Horowitz, Z
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Richardson, P
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Trechsel, U
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show more...
-
Widmer, A
-
Devogelaer, J
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Kaufman, J
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Jaeger, P
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Body, J
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Meunier, PJ
-
Samsioe, Göran
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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New England Jour ...
- By the university
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Lund University