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Patch testing with ...
Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy.
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- Pontén, Ann (author)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
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Aalto-Korte, Kristiina (author)
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Agner, Tove (author)
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Andersen, Klaus E (author)
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Giménez-Arnau, Ana M (author)
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Gonçalo, Margarida (author)
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Goossens, An (author)
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Johansen, Jeanne D (author)
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Le Coz, Christophe J (author)
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Maibach, Howard I (author)
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Rustemeyer, Thomas (author)
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White, Ian R (author)
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- Bruze, Magnus (author)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
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(creator_code:org_t)
- 2012-10-05
- 2013
- English.
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In: Contact Dermatitis. - : Wiley. - 0105-1873. ; 68:1, s. 50-53
- Related links:
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Abstract
Subject headings
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- Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p < 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- dose
- contact allergy
- false-negative
- formaldehyde
- micropipette
- patch
- test
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Pontén, Ann
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Aalto-Korte, Kri ...
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Agner, Tove
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Andersen, Klaus ...
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Giménez-Arnau, A ...
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Gonçalo, Margari ...
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show more...
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Goossens, An
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Johansen, Jeanne ...
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Le Coz, Christop ...
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Maibach, Howard ...
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Rustemeyer, Thom ...
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White, Ian R
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Bruze, Magnus
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
- Articles in the publication
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Contact Dermatit ...
- By the university
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Lund University