Screening of some European medicinal plants for spasmolytic activity on isolated guinea-pig trachea

Eight European plants, used traditionally against diseases of the respiratory system, have been assayed for in vitro spasmolytic activity on guinea-pig trachea. The plants were collected or cultivated in the south of Sweden, and both water and 67% methanol extracts of the parts reported to be used in the traditional medicine were prepared and assayed. Five of the species did not show any significant activity at concentrations up to 0.6 mg extract per ml organ bath, the methanol extracts of 2 species (Glechoma hederacea and Hyssopus officinale) showed weak activity, while 0.6 mg/ml of the methanol extract of the aerial parts of Artemisia abrotanum relaxed the tone induced by 0.1 μmol/l carbachol almost (80%) as effectively as 2.2 mmol/l terbutaline.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
artemisia abrotanum extract
plant extract
terbutaline
unclassified drug
animal tissue
controlled study
drug screening
guinea pig
male
medicinal plant
nonhuman
short survey
spasmolysis
Sweden
trachea

Franzen, C. (author)
Jeppsson, A.-B. (author)
Sterner, O.Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ok2-ost (author)
Waldeck, B. (author)
Centrum för analys och syntesKemiska institutionen (creator_code:org_t)

By the author/editor: Bergendorff, O.; Franzen, C.; Jeppsson, A.-B.; Sterner, O.; Waldeck, B.

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmaceutical S ...

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