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Effect of High-Risk...
Effect of High-Risk Obstructive Sleep Apnea on Clinical Outcomes in Adults with Coronavirus Disease 2019
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- Peker, Yuksel (författare)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Sahlgrenska Academy,Koc University,University of Pittsburgh
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- Celik, Yeliz (författare)
- Koc University
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- Arbatli, Semih (författare)
- Koc University
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- Isik, Sacide Rana (författare)
- Koc Healthcare American Hospital, Istanbul
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- Balcan, Baran (författare)
- Koc Healthcare American Hospital, Istanbul
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- Karataş, Ferhan (författare)
- Koc University
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- Uzel, Fatma Işıl (författare)
- Koc University
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- Tabak, Levent (författare)
- Koc Healthcare American Hospital, Istanbul
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- Çetin, Betul (författare)
- Marmara University Hospital
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- Baygul, Arzu (författare)
- Koc University
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- Ozturk, Ayşe Bilge (författare)
- Koc University
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- Altug, Elif (författare)
- Koc Healthcare American Hospital, Istanbul
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- Iliaz, Sinem (författare)
- Koc University
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- Atasoy, Cetin (författare)
- Koc University
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- Kapmaz, Mahir (författare)
- Koc University
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- Yazici, Duygu (författare)
- Koc University
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- Bayram, Hasan (författare)
- Koc University
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- Çetin, Birsen Durmaz (författare)
- Koc University
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- Çaglayan, Benan (författare)
- Koc University
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(creator_code:org_t)
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- 2021
- 2021
- Engelska 12 s.
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Ingår i: Annals of the American Thoracic Society. - 2329-6933. ; 18:9, s. 1548-1559
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Rationale: Coronavirus disease (COVID-19) is an ongoing pandemic, in which obesity, hypertension, and diabetes have been linked to poor outcomes. Obstructive sleep apnea (OSA) is associated with these conditions and may influence the prognosis of adults with COVID-19. Objectives: To determine the effect of OSA on clinical outcomes in patients with COVID-19. Methods: The current prospective observational study was conducted in three hospitals in Istanbul, Turkey from March 10 to June 22, 2020. The participants were categorized as high-risk or low-risk OSA according to the Berlin questionnaire that was administered in the out-patient clinic, in hospital, or shortly after discharge from hospital blinded to the clinical outcomes. A modified high-risk (mHR)–OSA score based on the snoring patterns (intensity and/or frequency), breathing pauses, and morning/daytime sleepiness, without taking obesity and hypertension into account, were used in the regression models. Results: The primary outcome was the clinical improvement defined as a decline of two categories from admission on a 7-category ordinal scale that ranges from 1 (discharged with normal activity) to 7 (death) on Days 7, 14, 21, and 28, respectively. Secondary outcomes included clinical worsening (an increase of 1 category), need for hospitalization, supplemental oxygen, and intensive care. In total, 320 eligible patients (median [interquartile range] age, 53.2 [41.3–63.0] yr; 45.9% female) were enrolled. In all, 121 (37.8%) were categorized as known (n = 3) or high-risk OSA (n = 118). According to the modified scoring, 70 (21.9%) had mHR-OSA. Among 242 patients requiring hospitalization, clinical improvement within 2 weeks occurred in 75.4% of the mHR-OSA group compared with 88.4% of the modified low-risk–OSA group (P = 0.014). In multivariate regression analyses, mHR-OSA (adjusted odds ratio [OR], 0.42; 95% confidence interval [CI], 0.19–0.92) and male sex (OR, 0.39; 95% CI, 0.17–0.86) predicted the delayed clinical improvement. In the entire study population (n = 320), including the nonhospitalized patients, mHR-OSA was associated with clinical worsening (adjusted hazard ratio, 1.55; 95% CI, 1.00–2.39) and with the need for supplemental oxygen (OR, 1.95; 95% CI, 1.06–3.59). Snoring patterns, especially louder snoring, significantly predicted delayed clinical improvement, worsening, need for hospitalization, supplemental oxygen, and intensive care. Conclusions: Adults with mHR-OSA in our COVID-19 cohort had poorer clinical outcomes than those with modified low-risk OSA independent of age, sex, and comorbidities. Clinical trial registered with www.clinicaltrials.gov (NCT04363333).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Clinical outcomes
- COVID-19
- Hospitalization
- Intensive care
- Obstructive sleep apnea
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Peker, Yuksel
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Celik, Yeliz
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Arbatli, Semih
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Isik, Sacide Ran ...
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Balcan, Baran
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Karataş, Ferhan
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visa fler...
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Uzel, Fatma Işıl
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Tabak, Levent
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Çetin, Betul
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Baygul, Arzu
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Ozturk, Ayşe Bil ...
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Altug, Elif
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Iliaz, Sinem
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Atasoy, Cetin
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Kapmaz, Mahir
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Yazici, Duygu
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Bayram, Hasan
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Çetin, Birsen Du ...
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Çaglayan, Benan
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visa färre...
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