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The Vitamin D Receptor as a Prognostic Marker in Breast Cancer-A Cohort Study
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- Huss, Linnea (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Helsingborg Hospital
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- Gulz-Haake, Igis (författare)
- Lund University,Lunds universitet,Cancerepidemiologi & strål,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cancerepidemiology and radiation,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
- Nilsson, Emma (författare)
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- (creator_code:org_t)
- 2024
- 2024
- Engelska.
- Ingår i: Nutrients. - 2072-6643. ; 16:7, s. 1-15
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Previous research has indicated an association between the presence of the vitamin D receptor (VDR) in breast cancer tissue and a favorable prognosis. This study aimed to further evaluate the prognostic potential of VDR located in the nuclear membrane or nucleus (liganded). The VDR protein levels were analyzed using immunohistochemistry in tumor samples from 878 breast cancer patients from Lund, Sweden, included in the Breast Cancer and Blood Study (BCBlood) from October 2002 to June 2012. The follow-up for breast cancer events and overall survival was recorded until 30 June 2019. Univariable and multivariable survival analyses were conducted, both with complete case data and with missing data imputed using multiple imputation by chained equations (MICE). Tumor-specific positive nuclear membrane VDR(num) staining was associated with favorable tumor characteristics and a longer breast cancer free interval (BCFI; HR: 0.64; 95% CI: 0.44-0.95) and overall survival (OS; HR: 0.52; 95% CI: 0.34-0.78). Further analyses indicated that VDRnum status also was predictive of overall survival when investigated in relation to ER status. There were significant interactions between VDR and invasive tumor size (Pinteraction = 0.047), as well as mode of detection (Pinteraction = 0.049). VDRnum was associated with a longer BCFI in patients with larger tumors (HR: 0.36; 95% CI: 0.14-0.93) or clinically detected tumors (HR: 0.28; 95% CI: 0.09-0.83), while no association was found for smaller tumors and screening-detected tumors. Further studies are suggested to confirm our results and to evaluate whether VDR should and could be used as a prognostic and targetable marker in breast cancer diagnostics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Humans
- Female
- Breast Neoplasms/diagnosis
- Cohort Studies
- Receptors, Calcitriol
- Prognosis
- Breast
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Huss, Linnea
- Gulz-Haake, Igis
- Nilsson, Emma
- Tryggvadottir, H ...
- Nilsson, Linn
- Nodin, Björn
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- Jirström, Karin
- Isaksson, Karoli ...
- Jernström, Helen ...
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