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Lifestyle changes i...
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Botteri, EdoardoCancer Registry of Norway, Institute of Population-Based Cancer Research
(author)
Lifestyle changes in middle age and risk of cancer : evidence from the European Prospective Investigation into Cancer and Nutrition
- Article/chapterEnglish2024
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:31a21357-b713-483f-9504-0cf94a8d6ef4
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https://lup.lub.lu.se/record/31a21357-b713-483f-9504-0cf94a8d6ef4URI
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https://doi.org/10.1007/s10654-023-01059-4DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:154500117URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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In this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline and during follow-up. At both timepoints, we calculated a healthy lifestyle index (HLI) score based on cigarette smoking, alcohol consumption, body mass index and physical activity. HLI ranged from 0 (most unfavourable) to 16 (most favourable). We estimated the association between HLI change and risk of lifestyle-related cancers—including cancer of the breast, lung, colorectum, stomach, liver, cervix, oesophagus, bladder, and others—using Cox regression models. We reported hazard ratios (HR) with 95% confidence intervals (CI). Median time between the two questionnaires was 5.7 years, median age at follow-up questionnaire was 59 years. After the follow-up questionnaire, we observed 14,933 lifestyle-related cancers over a median follow-up of 7.8 years. Each unit increase in the HLI score was associated with 4% lower risk of lifestyle-related cancers (HR 0.96; 95%CI 0.95–0.97). Among participants in the top HLI third at baseline (HLI > 11), those in the bottom third at follow-up (HLI ≤ 9) had 21% higher risk of lifestyle-related cancers (HR 1.21; 95%CI 1.07–1.37) than those remaining in the top third. Among participants in the bottom HLI third at baseline, those in the top third at follow-up had 25% lower risk of lifestyle-related cancers (HR 0.75; 95%CI 0.65–0.86) than those remaining in the bottom third. These results indicate that lifestyle changes in middle age may have a significant impact on cancer risk.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Peveri, GiuliaKarolinska Institute,University of Milan
(author)
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Berstad, PaulaCancer Registry of Norway, Institute of Population-Based Cancer Research
(author)
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Bagnardi, VincenzoUniversity of Milano-Bicocca
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Hoff, GeirCancer Registry of Norway, Institute of Population-Based Cancer Research,Telemark Hospital
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Heath, Alicia K.Imperial College London
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Cross, Amanda J.Imperial College London
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Vineis, PaoloImperial College London
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Dossus, LaureInternational Agency for Research on Cancer, World Health Organization
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Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization
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Freisling, HeinzInternational Agency for Research on Cancer, World Health Organization
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Matta, KomodoInternational Agency for Research on Cancer, World Health Organization
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Huybrechts, IngeInternational Agency for Research on Cancer, World Health Organization
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Chen, Sairah L.F.UiT The Arctic University of Norway, Tromsø
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B. Borch, KristinUiT The Arctic University of Norway, Tromsø
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Sandanger, Torkjel M.UiT The Arctic University of Norway, Tromsø
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H. Nøst, ThereseUiT The Arctic University of Norway, Tromsø,Norwegian University of Science and Technology
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Dahm, Christina C.Aarhus University
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Antoniussen, Christian S.Aarhus University
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Tin Tin, SandarUniversity of Oxford
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Fournier, AgnèsVersailles Saint-Quentin-en-Yvelines University
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Marques, ChloéVersailles Saint-Quentin-en-Yvelines University
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Artaud, FannyVersailles Saint-Quentin-en-Yvelines University
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Sánchez, Maria JoséCIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP),University of Granada
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Guevara, MarcelaCIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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Santiuste, CarmenCIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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Agudo, AntonioBellvitge Biomedical Research Institute,Catalan Institute of Oncology
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Bajracharya, RashmitaGerman Cancer Research Centre
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Katzke, VerenaGerman Cancer Research Centre
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Ricceri, FulvioUniversity of Turin
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Agnoli, ClaudiaIstituto Nazionale dei Tumori
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Bergmann, Manuela M.German Institute of Human Nutrition
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Schulze, Matthias B.German Institute of Human Nutrition,University of Potsdam
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Panico, SalvatoreUniversity of Naples Federico II
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Masala, GiovannaInstitute for Cancer Research, Prevention and Clinical Network (ISPRO)
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Tjønneland, AnneDanish Cancer Society,University of Copenhagen
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Olsen, AnjaAarhus University,Danish Cancer Society
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Stocks, TanjaLund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Registerbaserad epidemiologi - Stocks,Institutionen för translationell medicin,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Register-based epidemiology,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)med-tss
(author)
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Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)smi-jma
(author)
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Aizpurua-Atxega, AmaiaBiodonostia Health Research Institute
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Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization
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Riboli, ElioImperial College London
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Gunter, Marc J.Imperial College London,International Agency for Research on Cancer, World Health Organization
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Ferrari, PietroInternational Agency for Research on Cancer, World Health Organization
(author)
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Karolinska InstituteCancer Registry of Norway, Institute of Population-Based Cancer Research
(creator_code:org_t)
Related titles
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In:European Journal of Epidemiology39:2, s. 147-1590393-2990
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In:European journal of epidemiology39:2, s. 147-1591573-7284
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- By the author/editor
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Botteri, Edoardo
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Peveri, Giulia
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Berstad, Paula
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Bagnardi, Vincen ...
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Hoff, Geir
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Heath, Alicia K.
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show more...
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Cross, Amanda J.
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Vineis, Paolo
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Dossus, Laure
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Johansson, Matti ...
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Freisling, Heinz
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Matta, Komodo
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Huybrechts, Inge
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Chen, Sairah L.F ...
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B. Borch, Kristi ...
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Sandanger, Torkj ...
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H. Nøst, Therese
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Dahm, Christina ...
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Antoniussen, Chr ...
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Tin Tin, Sandar
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Fournier, Agnès
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Marques, Chloé
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Artaud, Fanny
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Sánchez, Maria J ...
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Guevara, Marcela
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Santiuste, Carme ...
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Agudo, Antonio
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Bajracharya, Ras ...
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Katzke, Verena
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Ricceri, Fulvio
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Agnoli, Claudia
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Bergmann, Manuel ...
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Schulze, Matthia ...
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Panico, Salvator ...
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Masala, Giovanna
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Tjønneland, Anne
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Olsen, Anja
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Stocks, Tanja
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Manjer, Jonas
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Aizpurua-Atxega, ...
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Weiderpass, Elis ...
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Riboli, Elio
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Gunter, Marc J.
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Ferrari, Pietro
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- MEDICAL AND HEALTH SCIENCES
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and Cancer and Oncol ...
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Lund University
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Karolinska Institutet