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Lifestyle changes i...
Lifestyle changes in middle age and risk of cancer : evidence from the European Prospective Investigation into Cancer and Nutrition
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- Botteri, Edoardo (author)
- Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Peveri, Giulia (author)
- Karolinska Institute,University of Milan
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- Berstad, Paula (author)
- Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Bagnardi, Vincenzo (author)
- University of Milano-Bicocca
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- Hoff, Geir (author)
- Cancer Registry of Norway, Institute of Population-Based Cancer Research,Telemark Hospital
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- Heath, Alicia K. (author)
- Imperial College London
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- Cross, Amanda J. (author)
- Imperial College London
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- Vineis, Paolo (author)
- Imperial College London
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- Dossus, Laure (author)
- International Agency for Research on Cancer, World Health Organization
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- Johansson, Mattias (author)
- International Agency for Research on Cancer, World Health Organization
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- Freisling, Heinz (author)
- International Agency for Research on Cancer, World Health Organization
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- Matta, Komodo (author)
- International Agency for Research on Cancer, World Health Organization
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- Huybrechts, Inge (author)
- International Agency for Research on Cancer, World Health Organization
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- Chen, Sairah L.F. (author)
- UiT The Arctic University of Norway, Tromsø
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- B. Borch, Kristin (author)
- UiT The Arctic University of Norway, Tromsø
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- Sandanger, Torkjel M. (author)
- UiT The Arctic University of Norway, Tromsø
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- H. Nøst, Therese (author)
- UiT The Arctic University of Norway, Tromsø,Norwegian University of Science and Technology
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- Dahm, Christina C. (author)
- Aarhus University
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- Antoniussen, Christian S. (author)
- Aarhus University
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- Tin Tin, Sandar (author)
- University of Oxford
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- Fournier, Agnès (author)
- Versailles Saint-Quentin-en-Yvelines University
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- Marques, Chloé (author)
- Versailles Saint-Quentin-en-Yvelines University
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- Artaud, Fanny (author)
- Versailles Saint-Quentin-en-Yvelines University
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- Sánchez, Maria José (author)
- CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP),University of Granada
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- Guevara, Marcela (author)
- CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Santiuste, Carmen (author)
- CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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- Agudo, Antonio (author)
- Bellvitge Biomedical Research Institute,Catalan Institute of Oncology
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- Bajracharya, Rashmita (author)
- German Cancer Research Centre
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- Katzke, Verena (author)
- German Cancer Research Centre
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- Ricceri, Fulvio (author)
- University of Turin
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- Agnoli, Claudia (author)
- Istituto Nazionale dei Tumori
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- Bergmann, Manuela M. (author)
- German Institute of Human Nutrition
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- Schulze, Matthias B. (author)
- German Institute of Human Nutrition,University of Potsdam
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- Panico, Salvatore (author)
- University of Naples Federico II
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- Masala, Giovanna (author)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Tjønneland, Anne (author)
- Danish Cancer Society,University of Copenhagen
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- Olsen, Anja (author)
- Aarhus University,Danish Cancer Society
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- Stocks, Tanja (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Registerbaserad epidemiologi - Stocks,Institutionen för translationell medicin,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Register-based epidemiology,Department of Translational Medicine,Faculty of Medicine
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Aizpurua-Atxega, Amaia (author)
- Biodonostia Health Research Institute
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization
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- Riboli, Elio (author)
- Imperial College London
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- Gunter, Marc J. (author)
- Imperial College London,International Agency for Research on Cancer, World Health Organization
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- Ferrari, Pietro (author)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: European Journal of Epidemiology. - 0393-2990. ; 39:2, s. 147-159
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline and during follow-up. At both timepoints, we calculated a healthy lifestyle index (HLI) score based on cigarette smoking, alcohol consumption, body mass index and physical activity. HLI ranged from 0 (most unfavourable) to 16 (most favourable). We estimated the association between HLI change and risk of lifestyle-related cancers—including cancer of the breast, lung, colorectum, stomach, liver, cervix, oesophagus, bladder, and others—using Cox regression models. We reported hazard ratios (HR) with 95% confidence intervals (CI). Median time between the two questionnaires was 5.7 years, median age at follow-up questionnaire was 59 years. After the follow-up questionnaire, we observed 14,933 lifestyle-related cancers over a median follow-up of 7.8 years. Each unit increase in the HLI score was associated with 4% lower risk of lifestyle-related cancers (HR 0.96; 95%CI 0.95–0.97). Among participants in the top HLI third at baseline (HLI > 11), those in the bottom third at follow-up (HLI ≤ 9) had 21% higher risk of lifestyle-related cancers (HR 1.21; 95%CI 1.07–1.37) than those remaining in the top third. Among participants in the bottom HLI third at baseline, those in the top third at follow-up had 25% lower risk of lifestyle-related cancers (HR 0.75; 95%CI 0.65–0.86) than those remaining in the bottom third. These results indicate that lifestyle changes in middle age may have a significant impact on cancer risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Cancer risk
- Cohort study
- Healthy lifestyle index
- Lifestyle changes
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Botteri, Edoardo
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Peveri, Giulia
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Berstad, Paula
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Bagnardi, Vincen ...
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Hoff, Geir
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Heath, Alicia K.
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show more...
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Cross, Amanda J.
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Vineis, Paolo
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Dossus, Laure
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Johansson, Matti ...
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Freisling, Heinz
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Matta, Komodo
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Huybrechts, Inge
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Chen, Sairah L.F ...
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B. Borch, Kristi ...
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Sandanger, Torkj ...
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H. Nøst, Therese
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Dahm, Christina ...
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Antoniussen, Chr ...
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Tin Tin, Sandar
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Fournier, Agnès
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Marques, Chloé
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Artaud, Fanny
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Sánchez, Maria J ...
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Guevara, Marcela
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Santiuste, Carme ...
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Agudo, Antonio
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Bajracharya, Ras ...
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Katzke, Verena
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Ricceri, Fulvio
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Agnoli, Claudia
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Bergmann, Manuel ...
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Schulze, Matthia ...
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Panico, Salvator ...
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Masala, Giovanna
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Tjønneland, Anne
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Olsen, Anja
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Stocks, Tanja
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Manjer, Jonas
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Aizpurua-Atxega, ...
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Weiderpass, Elis ...
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Riboli, Elio
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Gunter, Marc J.
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Ferrari, Pietro
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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European Journal ...
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European journal ...
- By the university
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Lund University
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Karolinska Institutet