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  • Sichien, DorineGhent University (author)

IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • Elsevier BV,2016
  • 15 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:31fecae9-1772-4d59-8221-aba1bcc21486
  • https://lup.lub.lu.se/record/31fecae9-1772-4d59-8221-aba1bcc21486URI
  • https://doi.org/10.1016/j.immuni.2016.08.013DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Interferon regulatory factor-8 (IRF8) has been proposed to be essential for development of monocytes, plasmacytoid dendritic cells (pDCs) and type 1 conventional dendritic cells (cDC1s) and remains highly expressed in differentiated DCs. Transcription factors that are required to maintain the identity of terminally differentiated cells are designated “terminal selectors.” Using BM chimeras, conditional Irf8fl/fl mice and various promotors to target Cre recombinase to different stages of monocyte and DC development, we have identified IRF8 as a terminal selector of the cDC1 lineage controlling survival. In monocytes, IRF8 was necessary during early but not late development. Complete or late deletion of IRF8 had no effect on pDC development or survival but altered their phenotype and gene-expression profile leading to increased T cell stimulatory function but decreased type 1 interferon production. Thus, IRF8 differentially controls the survival and function of terminally differentiated monocytes, cDC1s, and pDCs.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Scott, Charlotte L.Ghent University (author)
  • Martens, LiesbetGhent University,Ghent University Hospital (author)
  • Vanderkerken, MatthiasGhent University Hospital,Ghent University (author)
  • Van Gassen, SofieGhent University (author)
  • Plantinga, MaudGhent University,Ghent University Hospital (author)
  • Joeris, ThorstenTechnical University of Denmark (author)
  • De Prijck, SofieGhent University (author)
  • Vanhoutte, LeenGhent University,Ghent University Hospital (author)
  • Vanheerswynghels, ManonGhent University,Ghent University Hospital (author)
  • Van Isterdael, GertGhent University Hospital,Ghent University (author)
  • Toussaint, WendyGhent University,Ghent University Hospital (author)
  • Madeira, Filipe BrancoGhent University,Ghent University Hospital (author)
  • Vergote, KarlGhent University Hospital,Ghent University (author)
  • Agace, William W.Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups,Technical University of Denmark(Swepub:lu)immu-wag (author)
  • Clausen, Björn E.Johannes-Gutenberg University Mainz (author)
  • Hammad, HamidaGhent University,Ghent University Hospital (author)
  • Dalod, MarcAix-Marseille University,Centre d'Immunologie Marseille Luminy (author)
  • Saeys, YvanGhent University,Ghent University Hospital (author)
  • Lambrecht, Bart N.Ghent University,Ghent University Hospital,Erasmus University Medical Center (author)
  • Guilliams, MartinGhent University (author)
  • Ghent UniversityGhent University Hospital (creator_code:org_t)

Related titles

  • In:Immunity: Elsevier BV45:3, s. 626-6401074-7613

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