Search: WFRF:(Sugihara Yutaka)
> (2017) >
Limited tumor tissu...
Limited tumor tissue drug penetration contributes to primary resistance against angiogenesis inhibitors
-
- Torok, Szilvia (author)
- Medical University of Vienna
-
- Rezeli, Melinda (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
-
- Kelemen, Olga (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
-
show more...
-
- Vegvari, Akos (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,University of Texas
-
- Watanabe, Kenichi (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
-
- Sugihara, Yutaka (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Tisza, Anna (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
-
- Marton, Timea (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
-
- Kovacs, Ildiko (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
-
- Tovari, Jozsef (author)
- National Institute of Oncology, Budapest
-
- Laszlo, Viktoria (author)
- Medical University of Vienna
-
- Helbich, Thomas H. (author)
- Medical University of Vienna
-
- Hegedus, Balazs (author)
- Medical University of Vienna
-
- Klikovits, Thomas (author)
- Medical University of Vienna
-
- Hoda, Mir Alireza (author)
- Medical University of Vienna
-
- Klepetko, Walter (author)
- Medical University of Vienna
-
- Paku, Sandor (author)
- Semmelweis University
-
- Marko-Varga, Gyorgy (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
-
- Dome, Balazs (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
-
show less...
-
(creator_code:org_t)
- Ivyspring International Publisher, 2017
- 2017
- English 13 s.
-
In: Theranostics. - : Ivyspring International Publisher. - 1838-7640. ; 7:2, s. 400-412
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
http://www.thno.org/...
-
https://lup.lub.lu.s...
-
https://doi.org/10.7...
-
show less...
Abstract
Subject headings
Close
- Resistance mechanisms against antiangiogenic drugs are unclear. Here, we correlated the antitumor and antivascular properties of five different antiangiogenic receptor tyrosine kinase inhibitors (RTKIs) (motesanib, pazopanib, sorafenib, sunitinib, vatalanib) with their intratumoral distribution data obtained by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI). In the first mouse model, only sunitinib exhibited broad-spectrum antivascular and antitumor activities by simultaneously suppressing vascular endothelial growth factor receptor-2 (VEGFR2) and desmin expression, and by increasing intratumoral hypoxia and inhibiting both tumor growth and vascularisation significantly. Importantly, the highest and most homogeneous intratumoral drug concentrations have been found in sunitinib-treated animals. In another animal model, where - in contrast to the first model - vatalanib was detectable at homogeneously high intratumoral concentrations, the drug significantly reduced tumor growth and angiogenesis. In conclusion, the tumor tissue penetration and thus the antiangiogenic and antitumor potential of antiangiogenic RTKIs vary among the tumor models and our study demonstrates the potential of MALDI-MSI to predict the efficacy of unlabelled small molecule antiangiogenic drugs in malignant tissue. Our approach is thus a major technical and preclinical advance demonstrating that primary resistance to angiogenesis inhibitors involves limited tumor tissue drug penetration. We also conclude that MALDI-MSI may significantly contribute to the improvement of antivascular cancer therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Angiogenesis
- Cancer
- Imaging mass spectrometry
- Matrix assisted laser desorption ionization
- Receptor tyrosine kinase inhibitor
- Resistance
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Torok, Szilvia
-
Rezeli, Melinda
-
Kelemen, Olga
-
Vegvari, Akos
-
Watanabe, Kenich ...
-
Sugihara, Yutaka
-
show more...
-
Tisza, Anna
-
Marton, Timea
-
Kovacs, Ildiko
-
Tovari, Jozsef
-
Laszlo, Viktoria
-
Helbich, Thomas ...
-
Hegedus, Balazs
-
Klikovits, Thoma ...
-
Hoda, Mir Alirez ...
-
Klepetko, Walter
-
Paku, Sandor
-
Marko-Varga, Gyo ...
-
Dome, Balazs
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Pharmacology and ...
- Articles in the publication
-
Theranostics
- By the university
-
Lund University