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Impact of the tcf7l...
Impact of the tcf7l2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia
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- Kristensen, Peter L. (författare)
- Nordsjællands Hospital
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- Pedersen-Bjergaard, Ulrik (författare)
- University of Copenhagen,Nordsjællands Hospital
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- Due-Andersen, Rikke (författare)
- Nordsjællands Hospital,Lægerne på Ellemarksvej
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- Høi-Hansen, Thomas (författare)
- Herlev Hospital,Nordsjællands Hospital
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- Grimmeshave, Lise (författare)
- Novo Nordisk A/S,Nordsjællands Hospital
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- Lyssenko, Valeriya (författare)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Genomik, diabetes och endokrinologi,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Genomics, Diabetes and Endocrinology,Steno Diabetes Center Copenhagen,Skåne University Hospital
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- Groop, Leif (författare)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Genomik, diabetes och endokrinologi,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Genomics, Diabetes and Endocrinology,Skåne University Hospital,University of Helsinki,Institute for Molecular Medicine Finland (FIMM)
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- Holst, Jens J. (författare)
- Panum Institute
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- Vaag, Allan A. (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Thorsteinsson, Birger (författare)
- Nordsjællands Hospital,University of Copenhagen
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(creator_code:org_t)
- 2016
- 2016
- Engelska 8 s.
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Ingår i: Endocrine Connections. - 2049-3614. ; 5:6, s. 53-60
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: In healthy carriers of the T allele of the transcription factor 7-like 2 (TCF7L2), fasting plasma glucagon concentrations are lower compared with those with the C allele. We hypothesised that presence of the T allele is associated with a diminished glucagon response during hypoglycaemia and a higher frequency of severe hypoglycaemia (SH) in type 1 diabetes (T1DM). Material and methods: This is a post hoc study of an earlier prospective observational study of SH and four mechanistic studies of physiological responses to hypoglycaemia. 269 patients with T1DM were followed in a one-year observational study. A log-linear negative binomial model was applied with events of SH as dependent variable and TCF7L2 alleles as explanatory variable. In four experimental studies including 65 people, TCF7L2 genotyping was done and plasma glucagon concentration during experimental hypoglycaemia was determined. Results: Incidences of SH were TT 0.54, TC 0.98 and CC 1.01 episodes per patient-year with no significant difference between groups. During experimental hypoglycaemia, the TCF7L2 polymorphism did not influence glucagon secretion. Discussion: Patients with T1DM carrying the T allele of the TCF7L2 polymorphism do not exhibit diminished glucagon response during hypoglycaemia and are not at increased risk of severe hypoglycaemia compared with carriers of the C allele.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Epidemiology
- Experimental hypoglycaemia
- Glucagon
- Severe hypoglycaemia
- TCF7L2
- Type 1 diabetes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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