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Safety profile of t...
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Salvestrini, ViolaCareggi University Hospital,University of Florence,Univ Florence, Italy; Azienda Osped Univ Careggi, Italy
(författare)
Safety profile of trastuzumab-emtansine (T-DM1) with concurrent radiation therapy : A systematic review and meta-analysis
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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ELSEVIER IRELAND LTD,2023
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:32fbcc12-d4ac-4ca4-8e13-6b7afd811d26
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https://lup.lub.lu.se/record/32fbcc12-d4ac-4ca4-8e13-6b7afd811d26URI
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https://doi.org/10.1016/j.radonc.2023.109805DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-197497URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:for swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Funding Agencies|National Institute of Health and Social Care Research (NIHR); NIHR Cambridge Biomedical Research Centre; Fondazione Radioterapia Oncologica (FRO); Fondazione Fiorenzo Fratini Onlus; Conad Societa Cooperativa; Fabiani Gioiellerie; Permira; Rinascente; Giorgio Tesi Group
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Background and Purpose: In recent years, the treatment landscape for breast cancer has undergone significant advancements, with the introduction of several new anticancer agents. One such agent is trastuzumab emtansine (T-DM1), an antibody drug conjugate that has shown improved outcomes in both early and advanced breast cancer. However, there is currently a lack of comprehensive evidence regarding the safety profile of combining T-DM1 with radiation therapy (RT). In this study, we aim to provide a summary of the available data on the safety of combining RT with T-DM1 in both early and metastatic breast cancer settings. Materials and Methods: This systematic review and meta-analysis project is part of the consensus recommendations by the European Society for Radiotherapy and Oncology (ESTRO) Guidelines Committee on integrating RT with targeted treatments for breast cancer. A thorough literature search was conducted using the PUBMED/MedLine, Embase, and Cochrane databases to identify original studies focusing on the safety profile of combining T-DM1 with RT. Results: After applying eligibility criteria, nine articles were included in the meta-analysis. Pooled data from these studies revealed a high incidence of grade 3 + radionecrosis (17%), while the rates of grade 3 + radiation-related pneumonitis (<1%) and skin toxicity (1%) were found to be very low. Conclusion: Although there is some concern regarding a slight increase in pneumonitis when combining T-DM1 with postoperative RT, the safety profile of this combination was deemed acceptable for locoregional treatment in non-metastatic breast cancer. However, caution is advised when irradiating intracranial sites concurrently with T-DM1. There is a pressing need for international consensus guidelines regarding the safety considerations of combining T-DM1 and RT for breast cancer.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kim, KyuboEwha Womans University,University of Florence,Univ Florence, Italy; Ewha Womans Univ, South Korea
(författare)
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Caini, SaverioInstitute for Cancer Research, Prevention and Clinical Network (ISPRO),Inst Canc Res Prevent & Clin Network ISPRO, Italy
(författare)
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Alkner, SaraLund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröstcancerbehandling,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast cancer treatment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Sweden; Lund Univ, Sweden(Swepub:lu)med-srt
(författare)
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Ekholm, MariaLinköpings universitet,Linköping University,Region Jönköping County,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Dept Oncol, Sweden(Swepub:liu)marek03
(författare)
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Skyttä, TanjaTampere University Hospital,Tampere Univ Hosp, Finland
(författare)
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Becherini, CarlottaCareggi University Hospital,University of Florence,Univ Florence, Italy; Azienda Osped Univ Careggi, Italy
(författare)
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Coles, Charlotte E.University of Cambridge,Univ Cambridge, England
(författare)
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Kaidar-Person, OritTel-Aviv University,Sheba Medical Center,Maastricht University,Sheba Med Ctr, Israel; Tel Aviv Univ, Israel; Maastricht Univ, Netherlands
(författare)
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Offersen, BirgitteAarhus University Hospital,Aarhus Univ Hosp, Denmark
(författare)
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de Azambuja, EvandroUniversité Libre de Bruxelles (ULB),Univ Libre Bruxelles ULB, Belgium
(författare)
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Visani, LucaCareggi University Hospital,University of Florence,Univ Florence, Italy
(författare)
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Cortes, JavierPangaea Oncology,European University of Madrid,Int Breast Canc Ctr IBCC, Spain; Univ Europea Madrid, Spain
(författare)
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Harbeck, NadiaUniversity Hospital Munich,LMU Univ Hosp, Germany
(författare)
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Rugo, Hope S.UCSF Helen Diller Family Comprehensive Cancer Center,UCSF Helen Diller Family Comprehens Canc Ctr, CA USA
(författare)
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Isacke, Clare M.Institute of Cancer Research London,Breast Canc Now Res Ctr, England
(författare)
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Marangoni, ElisabettaCurie Institute, Paris,Inst Curie, France
(författare)
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Morandi, AndreaUniversity of Florence,Univ Florence, Italy
(författare)
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Lambertini, MatteoUniversity of Genoa,Ospedale Policlinico San Martino,Univ Genoa, Italy; IRCCS Osped Policlin San Martino, Italy
(författare)
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Poortmans, PhilipIridium Netwerk, Belgium; Univ Antwerp, Belgium,University of Antwerp
(författare)
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Livi, LorenzoUniversity of Florence,Careggi University Hospital,Univ Florence, Italy; Azienda Osped Univ Careggi, Italy
(författare)
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Meattini, IcroCareggi University Hospital,University of Florence,Univ Florence, Italy; Azienda Osped Univ Careggi, Italy; Univ Florence, Italy
(författare)
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Careggi University HospitalUniversity of Florence
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Radiotherapy and Oncology: ELSEVIER IRELAND LTD1860167-81401879-0887
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Salvestrini, Vio ...
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Kim, Kyubo
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Caini, Saverio
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Alkner, Sara
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Ekholm, Maria
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Skyttä, Tanja
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visa fler...
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Becherini, Carlo ...
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Coles, Charlotte ...
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Kaidar-Person, O ...
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Offersen, Birgit ...
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de Azambuja, Eva ...
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Visani, Luca
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Cortes, Javier
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Harbeck, Nadia
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Rugo, Hope S.
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Isacke, Clare M.
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Marangoni, Elisa ...
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Morandi, Andrea
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Lambertini, Matt ...
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Poortmans, Phili ...
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Livi, Lorenzo
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Meattini, Icro
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