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Sökning: WFRF:(Isacke Clare M) > (2020-2023) > Safety profile of t...

  • Salvestrini, ViolaCareggi University Hospital,University of Florence,Univ Florence, Italy; Azienda Osped Univ Careggi, Italy (författare)

Safety profile of trastuzumab-emtansine (T-DM1) with concurrent radiation therapy : A systematic review and meta-analysis

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • ELSEVIER IRELAND LTD,2023

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:32fbcc12-d4ac-4ca4-8e13-6b7afd811d26
  • https://lup.lub.lu.se/record/32fbcc12-d4ac-4ca4-8e13-6b7afd811d26URI
  • https://doi.org/10.1016/j.radonc.2023.109805DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-197497URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:for swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Funding Agencies|National Institute of Health and Social Care Research (NIHR); NIHR Cambridge Biomedical Research Centre; Fondazione Radioterapia Oncologica (FRO); Fondazione Fiorenzo Fratini Onlus; Conad Societa Cooperativa; Fabiani Gioiellerie; Permira; Rinascente; Giorgio Tesi Group
  • Background and Purpose: In recent years, the treatment landscape for breast cancer has undergone significant advancements, with the introduction of several new anticancer agents. One such agent is trastuzumab emtansine (T-DM1), an antibody drug conjugate that has shown improved outcomes in both early and advanced breast cancer. However, there is currently a lack of comprehensive evidence regarding the safety profile of combining T-DM1 with radiation therapy (RT). In this study, we aim to provide a summary of the available data on the safety of combining RT with T-DM1 in both early and metastatic breast cancer settings. Materials and Methods: This systematic review and meta-analysis project is part of the consensus recommendations by the European Society for Radiotherapy and Oncology (ESTRO) Guidelines Committee on integrating RT with targeted treatments for breast cancer. A thorough literature search was conducted using the PUBMED/MedLine, Embase, and Cochrane databases to identify original studies focusing on the safety profile of combining T-DM1 with RT. Results: After applying eligibility criteria, nine articles were included in the meta-analysis. Pooled data from these studies revealed a high incidence of grade 3 + radionecrosis (17%), while the rates of grade 3 + radiation-related pneumonitis (<1%) and skin toxicity (1%) were found to be very low. Conclusion: Although there is some concern regarding a slight increase in pneumonitis when combining T-DM1 with postoperative RT, the safety profile of this combination was deemed acceptable for locoregional treatment in non-metastatic breast cancer. However, caution is advised when irradiating intracranial sites concurrently with T-DM1. There is a pressing need for international consensus guidelines regarding the safety considerations of combining T-DM1 and RT for breast cancer.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Kim, KyuboEwha Womans University,University of Florence,Univ Florence, Italy; Ewha Womans Univ, South Korea (författare)
  • Caini, SaverioInstitute for Cancer Research, Prevention and Clinical Network (ISPRO),Inst Canc Res Prevent & Clin Network ISPRO, Italy (författare)
  • Alkner, SaraLund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröstcancerbehandling,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast cancer treatment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Sweden; Lund Univ, Sweden(Swepub:lu)med-srt (författare)
  • Ekholm, MariaLinköpings universitet,Linköping University,Region Jönköping County,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Dept Oncol, Sweden(Swepub:liu)marek03 (författare)
  • Skyttä, TanjaTampere University Hospital,Tampere Univ Hosp, Finland (författare)
  • Becherini, CarlottaCareggi University Hospital,University of Florence,Univ Florence, Italy; Azienda Osped Univ Careggi, Italy (författare)
  • Coles, Charlotte E.University of Cambridge,Univ Cambridge, England (författare)
  • Kaidar-Person, OritTel-Aviv University,Sheba Medical Center,Maastricht University,Sheba Med Ctr, Israel; Tel Aviv Univ, Israel; Maastricht Univ, Netherlands (författare)
  • Offersen, BirgitteAarhus University Hospital,Aarhus Univ Hosp, Denmark (författare)
  • de Azambuja, EvandroUniversité Libre de Bruxelles (ULB),Univ Libre Bruxelles ULB, Belgium (författare)
  • Visani, LucaCareggi University Hospital,University of Florence,Univ Florence, Italy (författare)
  • Cortes, JavierPangaea Oncology,European University of Madrid,Int Breast Canc Ctr IBCC, Spain; Univ Europea Madrid, Spain (författare)
  • Harbeck, NadiaUniversity Hospital Munich,LMU Univ Hosp, Germany (författare)
  • Rugo, Hope S.UCSF Helen Diller Family Comprehensive Cancer Center,UCSF Helen Diller Family Comprehens Canc Ctr, CA USA (författare)
  • Isacke, Clare M.Institute of Cancer Research London,Breast Canc Now Res Ctr, England (författare)
  • Marangoni, ElisabettaCurie Institute, Paris,Inst Curie, France (författare)
  • Morandi, AndreaUniversity of Florence,Univ Florence, Italy (författare)
  • Lambertini, MatteoUniversity of Genoa,Ospedale Policlinico San Martino,Univ Genoa, Italy; IRCCS Osped Policlin San Martino, Italy (författare)
  • Poortmans, PhilipIridium Netwerk, Belgium; Univ Antwerp, Belgium,University of Antwerp (författare)
  • Livi, LorenzoUniversity of Florence,Careggi University Hospital,Univ Florence, Italy; Azienda Osped Univ Careggi, Italy (författare)
  • Meattini, IcroCareggi University Hospital,University of Florence,Univ Florence, Italy; Azienda Osped Univ Careggi, Italy; Univ Florence, Italy (författare)
  • Careggi University HospitalUniversity of Florence (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Radiotherapy and Oncology: ELSEVIER IRELAND LTD1860167-81401879-0887

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