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Iohexol plasma clea...
Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research : A review. Part 1: How to measure glomerular filtration rate with iohexol?
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- Delanaye, Pierre (författare)
- University of Liège Hospital
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- Ebert, Natalie (författare)
- Charité - University Medicine Berlin
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- Melsom, Toralf (författare)
- UiT The Arctic University of Norway, Tromsø
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- Gaspari, Flavio (författare)
- Mario Negri Institute for Pharmacological Research
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- Mariat, Christophe (författare)
- Jean Monnet University
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- Cavalier, Etienne (författare)
- University of Liège Hospital
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- Björk, Jonas (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Christensson, Anders (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Nyman, Ulf (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Skåne University Hospital
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- Porrini, Esteban (författare)
- University of La Laguna (ULL)
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- Remuzzi, Giuseppe (författare)
- Mario Negri Institute for Pharmacological Research
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- Ruggenenti, Piero (författare)
- Mario Negri Institute for Pharmacological Research
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- Schaeffner, Elke (författare)
- Charité - University Medicine Berlin
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- Soveri, Inga, 1978- (författare)
- Uppsala universitet,Uppsala University,Njurmedicin,Renal Medicine
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- Sterner, Gunnar (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Eriksen, Bjørn Odvar (författare)
- UiT The Arctic University of Norway, Tromsø
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- Bäck, Sten Erik (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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(creator_code:org_t)
- 2016-08-23
- 2016
- Engelska 18 s.
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Ingår i: Clinical Kidney Journal. - : Oxford University Press (OUP). - 2048-8505 .- 2048-8513. ; 9:5, s. 682-699
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://academic.oup...
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https://uu.diva-port... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- While there is general agreement on the necessity tomeasure glomerular filtration rate (GFR) inmany clinical situations, there is less agreement on the bestmethod to achieve this purpose. As the gold standardmethod for GFR determination, urinary (or renal) clearance of inulin, fades into the background due to inconvenience and high cost, a diversity of filtrationmarkers and protocols compete to replace it. In this review, we suggest that iohexol, a non-ionic contrast agent, is most suited to replace inulin as the marker of choice for GFR determination. Iohexol comes very close to fulfilling all requirements for an ideal GFRmarker in terms of low extra-renal excretion, low protein binding and in being neither secreted nor reabsorbed by the kidney. In addition, iohexol is virtually non-Toxic and carries a low cost. As iohexol is stable in plasma, administration and sample analysis can be separated in both space and time, allowing access to GFR determination across different settings. An external proficiency programme operated by Equalis AB, Sweden, exists for iohexol, facilitating interlaboratory comparison of results. Plasma clearance measurement is the protocol of choice as it combines a reliable GFR determination with convenience for the patient. Single-sample protocols dominate, butmultiple-sample protocolsmay bemore accurate in specific situations. In lowGFRs one ormore late samples should be included to improve accuracy. In patients with large oedema or ascites, urinary clearance protocols should be employed. In conclusion, plasma clearance of iohexol may well be the best candidate for a common GFR determination method.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Glomerular filtration rate
- Iohexol
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- Av författaren/redakt...
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Delanaye, Pierre
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Ebert, Natalie
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Melsom, Toralf
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Gaspari, Flavio
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Mariat, Christop ...
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Cavalier, Etienn ...
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Björk, Jonas
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Christensson, An ...
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Nyman, Ulf
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Porrini, Esteban
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Remuzzi, Giusepp ...
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Ruggenenti, Pier ...
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Schaeffner, Elke
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Soveri, Inga, 19 ...
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Sterner, Gunnar
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Eriksen, Bjørn O ...
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Bäck, Sten Erik
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