New approaches for brain repair-from rescue to reprogramming

The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New approaches using stem-cell-derived cell products and direct cell reprogramming have opened up the possibility of reconstructing neural circuits and achieving better repair. In this Review we briefly summarize the history of neural repair and then discuss these new therapeutic approaches, especially with respect to chronic neurodegenerative disorders.

Götz, MagdalenaMunich Cluster for Systems Neurology,Ludwig-Maximilian University of Munich (författare)
Parmar, MalinLund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups(Swepub:lu)mphy-mpa (författare)
University of CambridgeMunich Cluster for Systems Neurology (creator_code:org_t)

Ingår i:Nature: Springer Science and Business Media LLC557:7705, s. 329-3340028-08361476-4687

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