Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials.

Many patients with asthma or chronic obstructive pulmonary disease (COPD) routinely receive a combination of an inhaled bronchodilator and anti-inflammatory glucocorticosteroid, but those with severe disease often respond poorly to these classes of drug. We assessed the efficacy and safety of a novel inhaled dual phosphodiesterase 3 (PDE3) and PDE4 inhibitor, RPL554 for its ability to act as a bronchodilator and anti-inflammatory drug.

Diamant, ZuzanaLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-zdt (author)
Banner, Katharine H (author)
Zuiker, Rob (author)
Morelli, Nicoletta (author)
Kamerling, Ingrid M C (author)
de Kam, Marieke L (author)
Burggraaf, Jacobus (author)
Cohen, Adam F (author)
Cazzola, Mario (author)
Calzetta, Luigino (author)
Singh, Dave (author)
Spina, Domenico (author)
Walker, Michael J A (author)
Page, Clive P (author)
Lungmedicin, allergologi och palliativ medicinSektion II (creator_code:org_t)

By the author/editor: Franciosi, Lui G; Diamant, Zuzana; Banner, Katharin ...; Zuiker, Rob; Morelli, Nicolet ...; Kamerling, Ingri ...; show more...; de Kam, Marieke ...; Burggraaf, Jacob ...; Cohen, Adam F; Cazzola, Mario; Calzetta, Luigin ...; Singh, Dave; Spina, Domenico; Walker, Michael ...; Page, Clive P; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.