Search: WFRF:(Dagli M.) >
A toxicologic and d...
A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients
-
Belsito, D. (author)
-
Bickers, D. (author)
-
- Bruze, Magnus (author)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
-
show more...
-
Calow, P. (author)
-
Dagli, M. (author)
-
Fryer, A. D. (author)
-
Greim, H. (author)
-
Miyachi, Y. (author)
-
Saurat, J. H. (author)
-
Sipes, I. G. (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
-
In: Food and Chemical Toxicology. - : Elsevier BV. - 0278-6915. ; 49:Suppl. 2, s. 256-267
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The cinnamyl phenylpropyl fragrance ingredients are a diverse group of chemical structures that have similar metabolic and toxicity profiles. A toxicological and dermatological review of these fragrance ingredients is presented. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. For high end users, calculated maximum dermal exposures vary from 0.14% to 0.72%; systemic exposures vary from 0.0002 to 0.0280 mg/kg/day. Human dermatological studies show that these materials are not generally irritants or sensitizers at lower exposures from consumer products. Reactions (0.9%) in fragrance sensitive patients were observed with 3-phenyl-1-propanol at 5% in petrolatum. The cinnamyl phenylpropyl materials had low acute toxicity and no significant toxicity in repeat dose oral or dermal toxicity studies. No mutagenic or genotoxic activity in bacteria and mammalian cell line assays was observed. The cinnamyl phenylpropyl alcohol materials participate in the same beta oxidation pathways as their parent cinnamic acid derivatives, including common routes of absorption, distribution, and metabolic detoxification, and exhibit similar toxicological endpoints. Based on the review of available data, it is concluded that these materials would not present a safety concern at current levels of use as fragrance ingredients. (C) 2011 Elsevier Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Review
- Safety
- Fragrance ingredients
- Cinnamyl phenylpropyl
Publication and Content Type
- for (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Belsito, D.
-
Bickers, D.
-
Bruze, Magnus
-
Calow, P.
-
Dagli, M.
-
Fryer, A. D.
-
show more...
-
Greim, H.
-
Miyachi, Y.
-
Saurat, J. H.
-
Sipes, I. G.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Pharmacology and ...
- Articles in the publication
-
Food and Chemica ...
- By the university
-
Lund University