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  • Hagell, PeterLund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Department of Health Sciences,Faculty of Medicine,Skåne University Hospital (author)

Sequential bilateral transplantation in Parkinson's disease: effects of the second graft

  • Article/chapterEnglish1999

Publisher, publication year, extent ...

  • Oxford University Press (OUP),1999

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:34c0957e-8abe-4244-9645-8dfd6bd43a4e
  • https://lup.lub.lu.se/record/1114613URI
  • https://doi.org/10.1093/brain/122.6.1121DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Five parkinsonian patients who had received implants of human embryonic mesencephalic tissue unilaterally in the striatum 10-56 months earlier were grafted with tissue from four to eight donors into the putamen (four patients) or the putamen plus the caudate nucleus (one patient) on the other side, and were followed for 18-24 months. After 12-18 months, PET showed a mean 85% increase in 6-L-[18F]fluorodopa uptake in the putamen with the second graft, whereas there was no significant further change in the previously transplanted putamen. Two patients exhibited marked additional improvements after their second graft: 'on-off' fluctuations virtually disappeared, movement speed increased, and L-dopa could be withdrawn in one patient and reduced by 70% in the other. The improvement in one patient was moderate. Two patients with atypical features, who responded poorly to the first graft, worsened following the second transplantation. These findings indicate that sequential transplantation in patients does not compromise the survival and function of either the first or the second graft. Moreover, putamen grafts that restore fluorodopa uptake to normal levels can give improvements of major therapeutic value.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Schrag, A (author)
  • Piccini, P (author)
  • Jahanshahi, M (author)
  • Brown, R (author)
  • Rehncrona, StigLund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)nkir-sre (author)
  • Widner, HåkanLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)mphy-hwi (author)
  • Brundin, PatrikLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)mphy-pbr (author)
  • Rothwell, J C (author)
  • Odin, PerLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-poi (author)
  • Wenning, G K (author)
  • Morrish, P (author)
  • Gustavii, B (author)
  • Björklund, AndersLund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups(Swepub:lu)mphy-abj (author)
  • Brooks, D J (author)
  • Marsden, C D (author)
  • Quinn, N P (author)
  • Lindvall, OlleLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)neur-oli (author)
  • Institutionen för hälsovetenskaperMedicinska fakulteten (creator_code:org_t)

Related titles

  • In:Brain: Oxford University Press (OUP)122:6, s. 1121-11321460-2156

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