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Combination of plas...
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Verberk, Inge M.W.Vrije Universiteit Amsterdam
(författare)
Combination of plasma amyloid beta(1-42/1-40)and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-09-28
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Springer Science and Business Media LLC,2020
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:3531247a-6ec9-4101-85d6-25d1f4a9cabe
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https://lup.lub.lu.se/record/3531247a-6ec9-4101-85d6-25d1f4a9cabeURI
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https://doi.org/10.1186/s13195-020-00682-7DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Background: Blood-based biomarkers for Alzheimer's disease (AD) might facilitate identification of participants for clinical trials targeting amyloid beta (Abeta) accumulation, and aid in AD diagnostics. We examined the potential of plasma markers Abeta(1-42/1-40), glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) to identify cerebral amyloidosis and/or disease severity. Methods: We included individuals with a positive (n = 176: 63 ± 7 years, 87 (49%) females) or negative (n = 76: 61 ± 9 years, 27 (36%) females) amyloid PET status, with syndrome diagnosis subjective cognitive decline (18 PET+, 25 PET-), mild cognitive impairment (26 PET+, 24 PET-), or AD-dementia (132 PET+). Plasma Abeta(1-42/1-40), GFAP, and NfL were measured by Simoa. We applied two-way ANOVA adjusted for age and sex to investigate the associations of the plasma markers with amyloid PET status and syndrome diagnosis; logistic regression analysis with Wald's backward selection to identify an optimal panel that identifies amyloid PET positivity; age, sex, and education-adjusted linear regression analysis to investigate associations between the plasma markers and neuropsychological test performance; and Spearman's correlation analysis to investigate associations between the plasma markers and medial temporal lobe atrophy (MTA). Results: Abeta(1-42/1-40) and GFAP independently associated with amyloid PET status (p = 0.009 and p < 0.001 respectively), and GFAP and NfL independently associated with syndrome diagnosis (p = 0.001 and p = 0.048 respectively). The optimal panel identifying a positive amyloid status included Abeta(1-42/1-40) and GFAP, alongside age and APOE (AUC = 88% (95% CI 83-93%), 82% sensitivity, 86% specificity), while excluding NfL and sex. GFAP and NfL robustly associated with cognitive performance on global cognition and all major cognitive domains (GFAP: range standardized β (sβ) = - 0.40 to - 0.26; NfL: range sβ = - 0.35 to - 0.18; all: p < 0.002), whereas Abeta(1-42/1-40) associated with global cognition, memory, attention, and executive functioning (range sβ = 0.22 - 0.11; all: p < 0.05) but not language. GFAP and NfL showed moderate positive correlations with MTA (both: Spearman's rho> 0.33, p < 0.001). Abeta(1-42/1-40) showed a moderate negative correlation with MTA (Spearman's rho = - 0.24, p = 0.001). Discussion and conclusions: Combination of plasma Abeta(1-42/1-40) and GFAP provides a valuable tool for the identification of amyloid PET status. Furthermore, plasma GFAP and NfL associate with various disease severity measures suggesting potential for disease monitoring.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Thijssen, ElisabethVrije Universiteit Amsterdam
(författare)
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Koelewijn, JannetVrije Universiteit Amsterdam
(författare)
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Mauroo, KimberleyADx NeuroSciences
(författare)
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Vanbrabant, JeroenADx NeuroSciences
(författare)
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De Wilde, ArnoVrije Universiteit Amsterdam
(författare)
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Zwan, Marissa D.Vrije Universiteit Amsterdam
(författare)
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Verfaillie, Sander C.J.Vrije Universiteit Amsterdam
(författare)
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Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam(Swepub:lu)ri1513os
(författare)
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Barkhof, FrederikUniversity College London
(författare)
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Van Berckel, Bart N.M.Vrije Universiteit Amsterdam
(författare)
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Scheltens, PhilipVrije Universiteit Amsterdam
(författare)
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Van Der Flier, Wiesje M.Vrije Universiteit Amsterdam
(författare)
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Stoops, ErikADx NeuroSciences
(författare)
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Vanderstichele, Hugo M.ADx NeuroSciences
(författare)
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Teunissen, Charlotte E.Vrije Universiteit Amsterdam
(författare)
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Vrije Universiteit AmsterdamADx NeuroSciences
(creator_code:org_t)
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Ingår i:Alzheimer's Research and Therapy: Springer Science and Business Media LLC12:11758-9193
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Verberk, Inge M. ...
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Thijssen, Elisab ...
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Koelewijn, Janne ...
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Mauroo, Kimberle ...
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Vanbrabant, Jero ...
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De Wilde, Arno
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Zwan, Marissa D.
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