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- Sohn, IbenCopenhagen University Hospital (author)
The effects of CGRP in vascular tissue - Classical vasodilation, shadowed effects and systemic dilemmas
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- Elsevier BV,2020
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:3580f701-360e-4f68-8f00-6bdc024c0b31
- https://lup.lub.lu.se/record/3580f701-360e-4f68-8f00-6bdc024c0b31URI
- https://doi.org/10.1016/j.ejphar.2020.173205DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Vascular tissue consists of endothelial cells, vasoactive smooth muscle cells and perivascular nerves. The perivascular sensory neuropeptide CGRP has demonstrated potent vasodilatory effects in any arterial vasculature examined so far, and a local protective CGRP-circuit of sensory nerve terminal CGRP release and smooth muscle cell CGRP action is evident. The significant vasodilatory effect has shadowed multiple other effects of CGRP in the vascular tissue and we therefore thoroughly review vascular actions of CGRP on endothelial cells, vascular smooth muscle cells and perivascular nerve terminals. The actions beyond vasodilation includes neuronal re-uptake and neuromodulation, angiogenic, proliferative and antiproliferative, pro- and anti-inflammatory actions which vary depending on the target cell and anatomical location. In addition to the classical perivascular nerve-smooth muscle CGRP circuit, we review existing evidence for a shadowed endothelial autocrine pathway for CGRP. Finally, we discuss the impact of local and systemic actions of CGRP in vascular regulation and protection from hypertensive and ischemic heart conditions with special focus on therapeutic CGRP agonists and antagonists.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
- CGRP
- Endothelial cells
- Heart
- Ischemic heart
- Vascular effects
- Vascular smooth muscle cells
Added entries (persons, corporate bodies, meetings, titles ...)
- Sheykhzade, MajidUniversity of Copenhagen (author)
- Edvinsson, LarsLund University,Lunds universitet,Experimentell kärlforskning,Forskargrupper vid Lunds universitet,Experimental Vascular Research,Lund University Research Groups,Copenhagen University Hospital(Swepub:lu)med-led (author)
- Sams, AnetteCopenhagen University Hospital (author)
- Copenhagen University HospitalUniversity of Copenhagen (creator_code:org_t)
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- In:European Journal of Pharmacology: Elsevier BV8810014-2999
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