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Male breast cancer ...
Male breast cancer after childhood cancer : Systematic review and analyses in the PanCareSurFup cohort
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- Wang, Yuehan (author)
- Princess Maxima Center for Pediatric Oncology/Hematology
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- Reulen, Raoul C. (author)
- University of Birmingham
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- Kremer, Leontien C.M. (author)
- Wilhelmina Children’s Hospital,Academic Medical Center of University of Amsterdam (AMC)
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- de Vathaire, Florent (author)
- Institut Gustave Roussy
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- Haupt, Riccardo (author)
- Gaslini Children's Hospital
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- Zadravec Zaletel, Lorna (author)
- University of Ljubljana,Institute of Oncology, Ljubljana
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- Bagnasco, Francesca (author)
- Gaslini Children's Hospital
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- Demoor-Goldschmidt, Charlotte (author)
- Institut Gustave Roussy,CHU Angers
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- van Dorp, Willem J. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Haddy, Nadia (author)
- Institut Gustave Roussy
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- Hjorth, Lars (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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Jakab, Zsuzsanna (author)
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- Kuehni, Claudia E. (author)
- University of Bern,University Children's Hospital Bern
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- Lähteenmäki, Päivi M. (author)
- Turku University Hospital
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van der Pal, Helena J.H. (author)
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- Sacerdote, Carlotta (author)
- University of Turin
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- Skinner, Roderick (author)
- University of Newcastle upon Tyne,Great North Children's Hospital
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- Terenziani, Monica (author)
- Istituto Nazionale dei Tumori
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- Wesenberg, Finn (author)
- Oslo university hospital
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- Winther, Jeanette F. (author)
- Aarhus University Hospital,Danish Cancer Society
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- van Leeuwen, Flora E. (author)
- Antoni Van Leeuwenhoek Hospital
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- Hawkins, Mike M. (author)
- University of Birmingham
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Teepen, Jop C. (author)
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van Dalen, Elvira C. (author)
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- Ronckers, Cécile M. (author)
- Brandenburg Medical School Theodor Fontane
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English 21 s.
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In: European Journal of Cancer. - : Elsevier BV. - 0959-8049. ; 165, s. 27-47
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Background: Breast cancer is a well-recognised late adverse effect in female childhood cancer survivors (CCSs), especially after chest radiotherapy; information on subsequent male breast cancer (SMBC) is limited. We summarised the existing evidence on SMBC after childhood cancer in a systematic review and investigated the risk of SMBC among males in a Pan-European cohort. Methods: We searched Medline/PubMed for cohort studies and case reports/series that assessed SMBC after childhood cancer (≤21 years). Furthermore, we analysed data on SMBC in the PanCareSurFup cohort, reporting standardised incidence ratios (SIRs), absolute excess risks (AERs), and 5- and 10-year survival rates. Results: The systematic review included 38 of 7080 potentially eligible articles. Cohort-specific SMBC frequencies were 0–0.40% (31 studies). SMBC occurred after a follow-up ranging from 24.0 to 42.0 years. Nine case reports/series described 11 SMBC cases, occurring 11.0–42.5 years after primary childhood cancer. In the PanCareSurFup cohort (16 SMBC/37,738 males; 0.04%), we observed a 22.3-fold increased risk of SMBC relative to the general male population (95% CI 12.7–36.2; absolute excess risk/100,000 person-years: 2.3, 95% CI 1.3–3.7). The five- and ten-year survival rates after SMBC diagnosis were 60.3% (95% CI 35.6%–85.0%) and 43.0% (95% CI 16.1%–69.9%), respectively. Clear evidence of risk factors did not emerge from these comprehensive efforts. Conclusions: Compared to the general population, male CCSs have an elevated risk of developing subsequent breast cancer, although the absolute risk is low. Health care providers should be aware of this rare yet serious late effect; male CCSs with symptoms potentially related to SMBC warrant careful examination.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Childhood cancer survivors
- Cohort study
- Data analyses
- Late effects
- Male breast cancer
- Second cancer
- Systematic review
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Wang, Yuehan
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Reulen, Raoul C.
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Kremer, Leontien ...
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de Vathaire, Flo ...
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Haupt, Riccardo
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Zadravec Zaletel ...
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Bagnasco, France ...
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Demoor-Goldschmi ...
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van Dorp, Willem ...
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Haddy, Nadia
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Hjorth, Lars
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Jakab, Zsuzsanna
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Kuehni, Claudia ...
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Lähteenmäki, Päi ...
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van der Pal, Hel ...
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Sacerdote, Carlo ...
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Skinner, Roderic ...
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Terenziani, Moni ...
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Wesenberg, Finn
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Winther, Jeanett ...
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van Leeuwen, Flo ...
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Hawkins, Mike M.
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Teepen, Jop C.
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van Dalen, Elvir ...
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Ronckers, Cécile ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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European Journal ...
- By the university
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Lund University