A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

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Soranzo, Nicole (author)

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Article/chapterEnglish2009

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2009-10-11
Springer Science and Business Media LLC,2009

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LIBRIS-ID:oai:lup.lub.lu.se:35ce7307-30b7-473b-894a-c603d9c2d2b0
https://lup.lub.lu.se/record/1504853URI
https://doi.org/10.1038/ng.467DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.

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Spector, Tim D. (author)
Mangino, Massimo (author)
Kuehnel, Brigitte (author)
Rendon, Augusto (author)
Teumer, Alexander (author)
Willenborg, Christina (author)
Wright, Benjamin (author)
Chen, Li (author)
Li, Mingyao (author)
Salo, Perttu (author)
Voight, Benjamin F. (author)
Burns, Philippa (author)
Laskowski, Roman A. (author)
Xue, Yali (author)
Menzel, Stephan (author)
Altshuler, David (author)
Bradley, John R. (author)
Bumpstead, Suzannah (author)
Burnett, Mary-Susan (author)
Devaney, Joseph (author)
Doering, Angela (author)
Elosua, Roberto (author)
Epstein, Stephen E. (author)
Erber, Wendy (author)
Falchi, Mario (author)
Garner, Stephen F. (author)
Ghori, Mohammed J. R. (author)
Goodall, Alison H. (author)
Gwilliam, Rhian (author)
Hakonarson, Hakon H. (author)
Hall, Alistair S. (author)
Hammond, Naomi (author)
Hengstenberg, Christian (author)
Illig, Thomas (author)
Koenig, Inke R. (author)
Knouff, Christopher W. (author)
McPherson, Ruth (author)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
Mooser, Vincent (author)
Nauck, Matthias (author)
Nieminen, Markku S. (author)
O'Donnell, Christopher J. (author)
Peltonen, Leena (author)
Potter, Simon C. (author)
Prokisch, Holger (author)
Rader, Daniel J. (author)
Rice, Catherine M. (author)
Roberts, Robert (author)
Salomaa, Veikko (author)
Sambrook, Jennifer (author)
Schreiber, Stefan (author)
Schunkert, Heribert (author)
Schwartz, Stephen M. (author)
Serbanovic-Canic, Jovana (author)
Sinisalo, Juha (author)
Siscovick, David S. (author)
Stark, Klaus (author)
Surakka, Ida (author)
Stephens, Jonathan (author)
Thompson, John R. (author)
Voelker, Uwe (author)
Voelzke, Henry (author)
Watkins, Nicholas A. (author)
Wells, George A. (author)
Wichmann, H-Erich (author)
Van Heel, David A. (author)
Tyler-Smith, Chris (author)
Thein, Swee Lay (author)
Kathiresan, Sekar (author)
Perola, Markus (author)
Reilly, Muredach P. (author)
Stewart, Alexandre F. R. (author)
Erdmann, Jeanette (author)
Samani, Nilesh J. (author)
Meisinger, Christa (author)
Greinacher, Andreas (author)
Deloukas, Panos (author)
Ouwehand, Willem H. (author)
Gieger, Christian (author)
Kardiovaskulär forskning - hypertoniForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC41:11, s. 38-11821546-17181061-4036

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By the author/editor: Soranzo, Nicole; Spector, Tim D.; Mangino, Massimo; Kuehnel, Brigitt ...; Rendon, Augusto; Teumer, Alexande ...; show more...; Willenborg, Chri ...; Wright, Benjamin; Chen, Li; Li, Mingyao; Salo, Perttu; Voight, Benjamin ...; Burns, Philippa; Laskowski, Roman ...; Xue, Yali; Menzel, Stephan; Altshuler, David; Bradley, John R.; Bumpstead, Suzan ...; Burnett, Mary-Su ...; Devaney, Joseph; Doering, Angela; Elosua, Roberto; Epstein, Stephen ...; Erber, Wendy; Falchi, Mario; Garner, Stephen ...; Ghori, Mohammed ...; Goodall, Alison ...; Gwilliam, Rhian; Hakonarson, Hako ...; Hall, Alistair S ...; Hammond, Naomi; Hengstenberg, Ch ...; Illig, Thomas; Koenig, Inke R.; Knouff, Christop ...; McPherson, Ruth; Melander, Olle; Mooser, Vincent; Nauck, Matthias; Nieminen, Markku ...; O'Donnell, Chris ...; Peltonen, Leena; Potter, Simon C.; Prokisch, Holger; Rader, Daniel J.; Rice, Catherine ...; Roberts, Robert; Salomaa, Veikko; Sambrook, Jennif ...; Schreiber, Stefa ...; Schunkert, Herib ...; Schwartz, Stephe ...; Serbanovic-Canic ...; Sinisalo, Juha; Siscovick, David ...; Stark, Klaus; Surakka, Ida; Stephens, Jonath ...; Thompson, John R ...; Voelker, Uwe; Voelzke, Henry; Watkins, Nichola ...; Wells, George A.; Wichmann, H-Eric ...; Van Heel, David ...; Tyler-Smith, Chr ...; Thein, Swee Lay; Kathiresan, Seka ...; Perola, Markus; Reilly, Muredach ...; Stewart, Alexand ...; Erdmann, Jeanett ...; Samani, Nilesh J ...; Meisinger, Chris ...; Greinacher, Andr ...; Deloukas, Panos; Ouwehand, Willem ...; Gieger, Christia ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: Nature Genetics

By the university: Lund University

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