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Outcome of men with...
Outcome of men with relapse after adjuvant carboplatin for clinical stage i seminoma
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- Fischer, Stefanie (författare)
- Kantonsspital St Gallen
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- Tandstad, Torgrim (författare)
- St. Olav’s University Hospital
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- Wheater, Matthew (författare)
- University Hospital Southampton
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- Porfiri, Emilio (författare)
- University Hospitals Birmingham
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- Fléchon, Aude (författare)
- Centre Léon Bérard
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- Aparicio, Jorge (författare)
- University and Polytechnic Hospital la Fe
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- Klingbiel, Dirk (författare)
- SAKK Coordinating Center
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- Skrbinc, Breda (författare)
- Institute of Oncology, Ljubljana
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- Basso, Umberto (författare)
- Veneto Institute of Oncology
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- Shamash, Jonathan (författare)
- Barts Health NHS Trust
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- Lorch, Anja (författare)
- University Hospital of Düsseldorf
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- Dieckmann, Klaus-Peter (författare)
- Klinik für Urologie
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- Cohn-Cedermark, Gabriella (författare)
- Karolinska Institute,Karolinska University Hospital
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- Ståhl, Olof (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Chau, Caroline (författare)
- University Hospital Southampton
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- Arriola, Edurne (författare)
- University Hospital Southampton
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- Marti, Kalena (författare)
- University Hospitals Birmingham
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- Hutton, Paul (författare)
- University Hospitals Birmingham
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- Laguerre, Brigitte (författare)
- Centre Eugène Marquis
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- Maroto, Pablo (författare)
- Hospital de Sant Pau
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- Beyer, Jörg (författare)
- University Hospital of Zurich
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- Gillessen, Silke (författare)
- Kantonsspital St Gallen
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Kantonsspital St Gallen St Olav’s University Hospital (creator_code:org_t)
- 2017
- 2017
- Engelska 7 s.
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Ingår i: Journal of Clinical Oncology. - 0732-183X. ; 35:2, s. 194-
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Purpose Adjuvant carboplatin is one of three management strategies that may follow inguinal orchiectomy in clinical stage I seminoma. However, little is known about the outcome of patients who experience a relapse after such treatment. Patients and Methods Data from 185 patients who relapsed after adjuvant carboplatin between January 1987 and August 2013 at 31 centers/groups from 20 countries were collected and retrospectively analyzed. Primary outcomes were disease-free survival and overall survival. Secondary outcomes were time to, stage at, and treatment of relapse as well as rate of subsequent relapses. Results With a median follow-up of 53 months (95% CI, 48 to 60 months) the 5-year disease-free survival was 82% (95% CI, 77% to 89%), and the 5-year overall survival was 98% (95% CI, 95% to 100%). The median time from orchiectomy to relapse was 19 months (95% CI, 17 to 23 months); 15% (95% CI, 10% to 21%) of relapses occurred > 3 years after treatment. The majority of relapses were detected by computed tomography scan during routine follow-up, 98% in the International Germ Cell Cancer Collaborative Group good prognosis group. Chemotherapy was administered to 92% of patients, mostly as standard first-line treatment corresponding to stage; 8% of patients had additional local treatments. Only 28 patients experienced a second relapse. At last follow-up, 174 (94%) of 185 patients were alive without disease, and four patients with disease. Seven patients died, three of whom due to progressive disease. Conclusion Within the limitations of a retrospective analysis, the results suggest that the majority of patients who experience a relapse after adjuvant carboplatin for clinical stage I seminoma can be successfully treated with a cisplatin-based chemotherapy regimen adequate for stage. Because 15% of the relapses occurred > 3 years after adjuvant treatment, a minimum of 5 years follow-up is recommended.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Fischer, Stefani ...
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Tandstad, Torgri ...
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Wheater, Matthew
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Porfiri, Emilio
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Fléchon, Aude
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Aparicio, Jorge
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Klingbiel, Dirk
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Skrbinc, Breda
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Basso, Umberto
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Shamash, Jonatha ...
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Lorch, Anja
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Dieckmann, Klaus ...
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Cohn-Cedermark, ...
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Ståhl, Olof
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Chau, Caroline
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Arriola, Edurne
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Marti, Kalena
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Hutton, Paul
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Laguerre, Brigit ...
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Maroto, Pablo
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Beyer, Jörg
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Gillessen, Silke
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Lunds universitet
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Karolinska Institutet