Search: (WFRF:(Bruce Ian N.)) lar1:(lu) pers:(Isenberg David A.) pers:(Dooley M A) >
Construction of a f...
Construction of a frailty index as a novel health measure in systemic lupus erythematosus
-
- Legge, Alexandra (author)
- Dalhousie University
-
- Kirkland, Susan (author)
- Dalhousie University
-
- Rockwood, Kenneth (author)
- Dalhousie University
-
show more...
-
- Andreou, Pantelis (author)
- Dalhousie University
-
- Bae, Sang Cheol (author)
- Hanyang University
-
- Gordon, Caroline (author)
- University of Birmingham
-
- Romero-Diaz, Juanita (author)
- Instituto Nacional de Ciencias Médicas y Nutrición
-
- Sanchez-Guerrero, Jorge (author)
- Instituto Nacional de Ciencias Médicas y Nutrición
-
- Wallace, Daniel J. (author)
- Jonsson Comprehensive Cancer Center
-
- Bernatsky, Sasha (author)
- McGill University
-
Clarke, Ann E. (author)
-
- Merrill, Joan T. (author)
- Oklahoma Medical Research Foundation
-
- Ginzler, Ellen M. (author)
- SUNY Downstate Health Sciences University
-
- Fortin, Paul (author)
- Laval University
-
- Gladman, Dafna D. (author)
- University of Toronto
-
- Urowitz, Murray B. (author)
- University of Toronto
-
- Bruce, Ian N. (author)
- Manchester Academic Health Science Centre
-
- Isenberg, David A. (author)
- University College London
-
- Rahman, Anisur (author)
- University College London
-
- Alarcon, Graciela S. (author)
- University of Alabama
-
- Petri, Michelle (author)
- Johns Hopkins University
-
Khamashta, Munther A. (author)
-
- Dooley, M. A. (author)
- University of North Carolina
-
- Ramsey-Goldman, Rosalind (author)
- Northwestern University Feinberg School of Medicine
-
- Manzi, Susan (author)
- Allegheny Health Network
-
- Zoma, Asad A. (author)
- Hairmyres Hospital
-
- Aranow, Cynthia (author)
- Feinstein Institute for Medical Research
-
- MacKay, Meggan (author)
- Feinstein Institute for Medical Research
-
- Ruiz-Irastorza, Guillermo (author)
- University of the Basque Country
-
- Lim, S. Sam (author)
- Emory University
-
Inanc, Murat (author)
-
- Van Vollenhoven, Ronald F. (author)
- Karolinska Institutet,Karolinska Institute
-
- Jonsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
-
- Nived, Ola (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Ramos-Casals, Manuel (author)
- Hospital Clínic of Barcelona
-
- Kamen, Diane L. (author)
- Medical University of South Carolina
-
- Kalunian, Kenneth C. (author)
- University of California, San Diego
-
- Jacobsen, Soren (author)
- Copenhagen University Hospital
-
- Peschken, Christine A. (author)
- University of Manitoba
-
- Askanase, Anca (author)
- Indian Institute of Technology
-
- Hanly, John G. (author)
- Dalhousie University
-
show less...
-
(creator_code:org_t)
- 2019-04-15
- 2020
- English 10 s.
-
In: Journal of Rheumatology. - : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 47:1, s. 72-81
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
http://www.jrheum.or...
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Objective. To construct a Frailty Index (FI) as a measure of vulnerability to adverse outcomes among patients with systemic lupus erythematosus (SLE), using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort. Methods. The SLICC inception cohort consists of recently diagnosed patients with SLE followed annually with clinical and laboratory assessments. For this analysis, the baseline visit was defined as the first study visit at which sufficient information was available for construction of an FI. Following a standard procedure, variables from the SLICC database were evaluated as potential health deficits. Selected health deficits were then used to generate a SLICC-FI. The prevalence of frailty in the baseline dataset was evaluated using established cutpoints for FI values. Results. The 1683 patients with SLE (92.1% of the overall cohort) eligible for inclusion in the baseline dataset were mostly female (89%) with mean (SD) age 35.7 (13.4) years and mean (SD) disease duration 18.8 (15.7) months at baseline. Of 222 variables, 48 met criteria for inclusion in the SLICC-FI. Mean (SD) SLICC-FI was 0.17 (0.08) with a range from 0 to 0.51. At baseline, 27.1% (95% CI 25.0-29.2) of patients were classified as frail, based on SLICC-FI values > 0.21. Conclusion. The SLICC inception cohort permits feasible construction of an FI for use in patients with SLE. Even in a relatively young cohort of patients with SLE, frailty was common. The SLICC-FI may be a useful tool for identifying patients with SLE who are most vulnerable to adverse outcomes, but validation of this index is required prior to its use.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Cohort studies
- Outcome assessment
- Systemic lupus erythematosus
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Legge, Alexandra
-
Kirkland, Susan
-
Rockwood, Kennet ...
-
Andreou, Panteli ...
-
Bae, Sang Cheol
-
Gordon, Caroline
-
show more...
-
Romero-Diaz, Jua ...
-
Sanchez-Guerrero ...
-
Wallace, Daniel ...
-
Bernatsky, Sasha
-
Clarke, Ann E.
-
Merrill, Joan T.
-
Ginzler, Ellen M ...
-
Fortin, Paul
-
Gladman, Dafna D ...
-
Urowitz, Murray ...
-
Bruce, Ian N.
-
Isenberg, David ...
-
Rahman, Anisur
-
Alarcon, Graciel ...
-
Petri, Michelle
-
Khamashta, Munth ...
-
Dooley, M. A.
-
Ramsey-Goldman, ...
-
Manzi, Susan
-
Zoma, Asad A.
-
Aranow, Cynthia
-
MacKay, Meggan
-
Ruiz-Irastorza, ...
-
Lim, S. Sam
-
Inanc, Murat
-
Van Vollenhoven, ...
-
Jonsen, Andreas
-
Nived, Ola
-
Ramos-Casals, Ma ...
-
Kamen, Diane L.
-
Kalunian, Kennet ...
-
Jacobsen, Soren
-
Peschken, Christ ...
-
Askanase, Anca
-
Hanly, John G.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
- Articles in the publication
-
Journal of Rheum ...
- By the university
-
Lund University
-
Karolinska Institutet