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Diabetes mellitus a...
Diabetes mellitus and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition
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Tsilidis, Konstantinos K. (author)
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Allen, Naomi E. (author)
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Appleby, Paul N. (author)
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show more...
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Rohrmann, Sabine (author)
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Noethlings, Ute (author)
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Arriola, Larraitz (author)
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Gunter, Marc J. (author)
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Chajes, Veronique (author)
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Rinaldi, Sabina (author)
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Romieu, Isabelle (author)
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Murphy, Neil (author)
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Riboli, Elio (author)
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Tzoulaki, Ioanna (author)
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Kaaks, Rudolf (author)
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- Lukanova, Annekatrin (author)
- Umeå universitet,Patologi,Department of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
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Boeing, Heiner (author)
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Pischon, Tobias (author)
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Dahm, Christina C. (author)
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Overvad, Kim (author)
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Quiros, J. Ramon (author)
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Fonseca-Nunes, Ana (author)
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Molina-Montes, Esther (author)
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Gavrila Chervase, Diana (author)
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Ardanaz, Eva (author)
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Khaw, Kay T. (author)
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Wareham, Nick J. (author)
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Roswall, Nina (author)
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Tjonneland, Anne (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Trichopoulou, Antonia (author)
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Palli, Domenico (author)
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Pala, Valeria (author)
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Tumino, Rosario (author)
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Vineis, Paolo (author)
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Bueno-de-Mesquita, H. B(as) (author)
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- Malm, Johan (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Johansson, Mattias (author)
- Umeå universitet,Enheten för biobanksforskning,International Agency for Research on Cancer, Lyon, France
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- Stattin, Pär (author)
- Umeå universitet,Uppsala universitet,Urologkirurgi,Urologi och andrologi
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Travis, Ruth C. (author)
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Key, Timothy J. (author)
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(creator_code:org_t)
- 2014-06-03
- 2014
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 136:2, s. 372-381
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http://dx.doi.org/10...
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http://uu.diva-porta...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The current epidemiologic evidence suggests that men with type 2 diabetes mellitus may be at lower risk of developing prostate cancer, but little is known about its association with stage and grade of the disease. The association between self-reported diabetes mellitus at recruitment and risk of prostate cancer was examined in the European Prospective Investigation into Cancer and Nutrition (EPIC). Among 139,131 eligible men, 4,531 were diagnosed with prostate cancer over an average follow-up of 12 years. Multivariable hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models stratified by EPIC-participating center and age at recruitment, and adjusted for education, smoking status, body mass index, waist circumference, and physical activity. In a subset of men without prostate cancer, the cross-sectional association between circulating concentrations of androgens and insulin-like growth factor proteins with diabetes status was also investigated using linear regression models. Compared to men with no diabetes, men with diabetes had a 26% lower risk of prostate cancer (HR, 0.74; 95% CI, 0.63-0.86). There was no evidence that the association differed by stage (p-heterogeneity, 0.19) or grade (p-heterogeneity, 0.48) of the disease, although the numbers were small in some disease subgroups. In a subset of 626 men with hormone measurements, circulating concentrations of androstenedione, total testosterone and insulin-like growth factor binding protein-three were lower in men with diabetes compared to men without diabetes. This large European study has confirmed an inverse association between self-reported diabetes mellitus and subsequent risk of prostate cancer. What's new? Emerging evidence suggests that men with type 2 diabetes are at lower risk to develop prostate cancer. Using data obtained within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors show that the prostate cancer risk was, indeed, reduced by 26% in men with type 2 diabetes but no association with cancer stage or grade was observed. In a subset of men for whom data on circulating hormones were available, levels of androstenedione, total testosterone and insulin-like growth factor binding protein-three were lower in those with diabetes as compared to those without diabetes, giving clues to how having diabetes could affect prostate cancer development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- type 2 diabetes
- prostate cancer
- cohort study
- androgens
- insulin-like
- growth factor proteins
- androgens
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Tsilidis, Konsta ...
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Allen, Naomi E.
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Appleby, Paul N.
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Rohrmann, Sabine
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Noethlings, Ute
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Arriola, Larrait ...
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show more...
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Gunter, Marc J.
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Chajes, Veroniqu ...
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Rinaldi, Sabina
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Romieu, Isabelle
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Murphy, Neil
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Riboli, Elio
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Tzoulaki, Ioanna
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Kaaks, Rudolf
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Lukanova, Anneka ...
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Boeing, Heiner
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Pischon, Tobias
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Dahm, Christina ...
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Overvad, Kim
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Quiros, J. Ramon
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Fonseca-Nunes, A ...
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Molina-Montes, E ...
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Gavrila Chervase ...
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Ardanaz, Eva
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Khaw, Kay T.
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Wareham, Nick J.
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Roswall, Nina
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Tjonneland, Anne
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Lagiou, Pagona
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Trichopoulos, Di ...
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Trichopoulou, An ...
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Palli, Domenico
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Pala, Valeria
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Tumino, Rosario
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Vineis, Paolo
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Bueno-de-Mesquit ...
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Malm, Johan
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Orho-Melander, M ...
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Johansson, Matti ...
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Stattin, Pär
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Travis, Ruth C.
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Key, Timothy J.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Lund University
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Uppsala University
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Umeå University