Sökning: WFRF:(Yakoub Agha Ibrahim) >
Relatively favorabl...
Relatively favorable outcome after allogeneic stem cell transplantation for BCR-ABL1-positive AML : A survey from the acute leukemia working party of the European Society for blood and marrow transplantation (EBMT)
-
- Lazarevic, Vladimir Lj (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
-
- Labopin, Myriam (författare)
- Hospital Saint-Antoine
-
- Depei, Wu (författare)
- Soochow University
-
visa fler...
-
- Yakoub-Agha, Ibrahim (författare)
- Lille 2 University
-
- Huynh, Anne (författare)
- Institut Universitaire du Cancer Toulouse
-
- Ljungman, Per (författare)
- Karolinska Institutet,Karolinska University Hospital
-
- Schaap, Nicolaas (författare)
- Radboud University Nijmegen
-
- Cornelissen, Jan J. (författare)
- Erasmus University Medical Center
-
- Maillard, Natacha (författare)
- Poitiers University Hospital
-
- Pioltelli, Pietro (författare)
- University of Milano-Bicocca
-
- Gedde-Dahl, Tobias (författare)
- Oslo university hospital
-
- Lenhoff, Stig (författare)
- Skåne University Hospital
-
- Houhou, Mohamed (författare)
- Hospital Saint-Antoine
-
- Esteve, Jordi (författare)
- Hospital Clínic of Barcelona
-
- Mohty, Mohamad (författare)
- Hospital Saint-Antoine
-
- Nagler, Arnon (författare)
- Hospital Saint-Antoine
-
visa färre...
-
(creator_code:org_t)
- 2017-10-31
- 2018
- Engelska.
-
Ingår i: American Journal of Hematology. - : Wiley. - 0361-8609 .- 1096-8652. ; 93:1, s. 31-39
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://onlinelibrar...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- The aim of the study was to assess the role of allogeneic stem cell transplantation (SCT) in patients diagnosed with BCR-ABL1-positive acute myeloid leukemia (AML). Fifty-seven patients (median age, 48 years, range: 19-67) with BCR-ABL1 positive AML undergoing SCT were identified. The majority of the patients (70%) received a TKI before the transplant. At SCT 48 patients were in CR (45 in CR1), while 9 patients were transplanted in a more advanced stage of the disease. MRD was negative (BCR-ABL1/ABL<104) at time of SCT in 36.1% (14/40). After SCT, 16 (61.5%) out of 26 patients with MRD positive at transplantation reached MRD negativity. After a median follow-up of 6.3 years (0.7-14.2), NRM, RI, LFS, OS, and GRFS at 5 years were 18.1%, 37%, 44.2%, 53.8%, and 32.1%, respectively. The cumulative incidence of acute GvHD grade II-IV was 16.4%, incidence of chronic GvHD 24.9%, and of extensive cGvHD 21.4%, respectively. In patients who received SCT in CR1, 5-yr NRM, RI, LFS, OS, and GRFS were 15.9%, 36.4%, 46.5%, 59.4%, and 34.9%, respectively. Univariate analysis showed that age (<50 vs. ≥50 years) was associated with RI (5-yr: 22.7 vs. 50%), LFS (5-yr: 61.9 vs. 31.8%), and GRFS (5-yr: 52.4 vs. 18.2%), whereas MRD-negative status before SCT was associated with an improved GRFS (38.9 vs. 16.7%). We conclude that the outcome of patients <50 years of age with BCR-ABL1-positive AML receiving allogeneic SCT in CR is relatively favorable, possibly reflecting the beneficial effect of the use of TKI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Lazarevic, Vladi ...
-
Labopin, Myriam
-
Depei, Wu
-
Yakoub-Agha, Ibr ...
-
Huynh, Anne
-
Ljungman, Per
-
visa fler...
-
Schaap, Nicolaas
-
Cornelissen, Jan ...
-
Maillard, Natach ...
-
Pioltelli, Pietr ...
-
Gedde-Dahl, Tobi ...
-
Lenhoff, Stig
-
Houhou, Mohamed
-
Esteve, Jordi
-
Mohty, Mohamad
-
Nagler, Arnon
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
American Journal ...
- Av lärosätet
-
Lunds universitet
-
Karolinska Institutet