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CD103 + CD11b + mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin
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- Flores-Langarica, A. (author)
- University of Birmingham
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- Müller Luda, K. (author)
- Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups
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- Persson, E. K. (author)
- Lund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups
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- (creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English 12 s.
- In: Mucosal Immunology. - : Elsevier BV. - 1933-0219. ; 11:3, s. 681-692
- Journal article (peer-reviewed)
Abstract
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- Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103 + CD11b + (DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103 + CD11b ' (SP) are not required for these responses. The lack of this response correlated with a complete absence of sFliC-specific plasma cells in the MLN, small intestinal lamina propria, and surprisingly also the bone marrow (BM). Many sFliC-specific plasma cells accumulating in the BM of immunized wild-type mice expressed α 4 β 7 +, suggesting a mucosal origin. Collectively, these results suggest that mucosal DP cDC contribute to the generation of the sFliC-specific plasma cell pool in the BM and thus serve as a bridge linking the mucosal and systemic immune system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- Flores-Langarica ...
- Müller Luda, K.
- Persson, E. K.
- Cook, C. N.
- Bobat, S.
- Marshall, J. L.
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- Dahlgren, M. W.
- Hägerbrand, K.
- Toellner, K. M.
- Goodall, M. D.
- Withers, D. R.
- Henderson, I. R.
- Johansson Lindbo ...
- Cunningham, A. F ...
- Agace, W. W.
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