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The influence of wa...
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Reslow, MatsLund University
(författare)
The influence of water on protease‐catalyzed peptide synthesis in acetonitrile/water mixtures
- Artikel/kapitelEngelska1988
Förlag, utgivningsår, omfång ...
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2005-03-03
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Wiley,1988
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6 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:36f79471-81e1-4c99-b962-191240249de2
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https://lup.lub.lu.se/record/36f79471-81e1-4c99-b962-191240249de2URI
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https://doi.org/10.1111/j.1432-1033.1988.tb14377.xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Protease‐catalyzed peptide synthesis in acetonitrile water mixtures, containing 0–90% water, was investigated. α‐Chymotrypsin, as well as thermolysin, were deposited on solid supports, prior to exposure to the reaction media. Peptide syntheses were performed using both a kinetically controlled process (chymotrypsin) and an equilibrium‐controlled synthesis (thermolysin). The activity of chymotrypsin decreased at low water contents. However, at low water contents (1–10%) hydrolytic side reactions were suppressed and high yields of dipeptides were obtained. Optimal water content for the thermolysin‐catalyzed reaction was 4–8%. The dipeptides produced were fully soluble in the reaction mixtures. High operational stability for α‐chymotrypsin was obtained during 216 h of reaction.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Adlercreutz, PatrickLund University,Lunds universitet,Bioteknik,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biotechnology,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)biot-pad
(författare)
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Mattiasson, BoLund University,Lunds universitet,Bioteknik,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biotechnology,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)biot-bma
(författare)
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Lund UniversityBioteknik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Biochemistry: Wiley177:2, s. 313-3180014-2956
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