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Demonstration of th...
Demonstration of the non-identity between the Fc receptor for human IgG from group A streptococci type 15 and M protein, peptidoglycan and the group specific carbohydrate
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Christensen, P (författare)
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- Grubb, A (författare)
- Lund University,Lunds universitet,Cystatin C, njursjukdom, amyloidos och antibiotika,Forskargrupper vid Lunds universitet,Cystatin C, renal disease, amyloidosis and antibiotics,Lund University Research Groups
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Grubb, R (författare)
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Samuelsson, G (författare)
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Schalén, C (författare)
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Svensson, M L (författare)
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(creator_code:org_t)
- 1979
- 1979
- Engelska.
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Ingår i: Acta Pathologica et Microbiologica Scandinavica. Section C, Immunology. - 0304-1328. ; 87C:3, s. 61-257
- Relaterad länk:
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https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- After electrophoresis of an alkaline extract of type 15 group A streptococci, three main precipitation lines were obtained in diffusion experiments against commercial human polyclonal IgG (lines 1, 2 and 3). Nineteen of 23 sera (83%) from apparently healthy human individuals gave line 3, while 6 of them (26%) gave line 1. The sera giving line 1 did also give line 3. Line 2 was obtained with 2 sera only, also giving lines 1 and 3. Line 3 was caused by a streptococcal Fc-receptor for human IgG, since the line could be displaced by addition of Fc-fragments, but not Fab-fragments of pooled human IgG. Line 1 was shown to be different from line 3, since (1) line 1 was suppressed in contrast to line 3 on absorption of a human serum or commercial polyclonal human IgG with S. aureus; and (2), line 1 was suppressed by Fab-fragments but not Fc-fragments of polyclonal human IgG. Line 2 could be inhibited by addition of peptidoglycan to commercial polyclonal human IgG or a human serum investigated. Another line, 4, obtained in diffusion experiments involving electrophoretically separated alkaline extract of type 15 group A streptococci was type-specific as shown by rabbit antisera to streptococci type M1, M8, M15, and T44, and disappeared on trypsinization of the extract. The component responsible for line 4 in the streptococcal extract, judged to be type-specific M protein, had a mobility different from the component responsible for line 3 in electrophoresis.
Nyckelord
- Bacterial Proteins/immunology
- Glycoproteins/immunology
- Humans
- Immunoglobulin Fc Fragments/isolation & purification
- Peptidoglycan/immunology
- Streptococcus pyogenes/immunology
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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