The relationship between the metabolic syndrome and arterial wall thickness : A mosaic still to be interpreted

Background and aims We aimed to identify clusters of metabolic syndrome (MetS) components, risky for extremely high intima-media thickness. Methods We studied 41,513 volunteers (men and women) from eleven cohorts worldwide, participating in the MARE (Metabolic syndrome and Artery REsearch) Consortium. Results Specific clusters of MetS components - high triglycerides-high blood pressure-abdominal obesity (TBW), low HDL cholesterol-high blood pressure-abdominal obesity (HBW), high glucose-high blood pressure-abdominal obesity (GBW) - were accompanied by a 50–90% significantly greater likelihood of presenting extremely high intima-media thickness (via ultrasound of carotid artery, CCA IMT), after controlling for age, sex, smoking, non-HDL cholesterol, and presence of diabetes mellitus. This likelihood is comparable to the effect of being 7–8 years older or of being a cigarette smoker or of having non-HDL cholesterol 50 mg/dl higher. Conclusions The consistent association of specific clusters of MetS components with extremely thick (older) large artery cross-culturally suggests that identification of those clusters in clinical practice will facilitate a personalized health care and a better – i.e. more healthy and cost-effective - prevention of major cardiovascular (CV) events.

Franco, Oscar H.Erasmus University Medical Center (författare)
Völzke, HenryUniversity of Greifswald (författare)
Shin, Min HoChonnam National University (författare)
Kweon, Sun SeogChonnam National University (författare)
Rietzschel, ErnstGhent University Hospital,Ghent University (författare)
Ryliškytė, LigitaVilnius University Hospital (författare)
Strazhesko, IrinaFederal State Institution National Research Center for Preventive Medicine, Russia (författare)
Chen, Chen HuanNational Yang-Ming University Taiwan (författare)
Lakatta, Edward G.National Institute on Aging, United States (författare)
Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (författare)
University of Rome Tor VergataErasmus University Medical Center (creator_code:org_t)

Av författaren/redakt...: Scuteri, Angelo; Franco, Oscar H.; Völzke, Henry; Shin, Min Ho; Kweon, Sun Seog; Rietzschel, Erns ...; visa fler...; Ryliškytė, Ligit ...; Strazhesko, Irin ...; Chen, Chen Huan; Lakatta, Edward ...; Nilsson, Peter M ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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