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  • Rando, Halie MUniversity of Colorado School of Medicine,University of Pennsylvania (author)

Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021
  • 32 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:387b0bb7-093f-4d19-b904-5dbcfdec3316
  • https://lup.lub.lu.se/record/387b0bb7-093f-4d19-b904-5dbcfdec3316URI
  • https://doi.org/10.1128/mSystems.00095-21DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:for swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The novel coronavirus SARS-CoV-2, which emerged in late 2019, has since spread around the world and infected hundreds of millions of people with coronavirus disease 2019 (COVID-19). While this viral species was unknown prior to January 2020, its similarity to other coronaviruses that infect humans has allowed for rapid insight into the mechanisms that it uses to infect human hosts, as well as the ways in which the human immune system can respond. Here, we contextualize SARS-CoV-2 among other coronaviruses and identify what is known and what can be inferred about its behavior once inside a human host. Because the genomic content of coronaviruses, which specifies the virus's structure, is highly conserved, early genomic analysis provided a significant head start in predicting viral pathogenesis and in understanding potential differences among variants. The pathogenesis of the virus offers insights into symptomatology, transmission, and individual susceptibility. Additionally, prior research into interactions between the human immune system and coronaviruses has identified how these viruses can evade the immune system's protective mechanisms. We also explore systems-level research into the regulatory and proteomic effects of SARS-CoV-2 infection and the immune response. Understanding the structure and behavior of the virus serves to contextualize the many facets of the COVID-19 pandemic and can influence efforts to control the virus and treat the disease. IMPORTANCE COVID-19 involves a number of organ systems and can present with a wide range of symptoms. From how the virus infects cells to how it spreads between people, the available research suggests that these patterns are very similar to those seen in the closely related viruses SARS-CoV-1 and possibly Middle East respiratory syndrome-related CoV (MERS-CoV). Understanding the pathogenesis of the SARS-CoV-2 virus also contextualizes how the different biological systems affected by COVID-19 connect. Exploring the structure, phylogeny, and pathogenesis of the virus therefore helps to guide interpretation of the broader impacts of the virus on the human body and on human populations. For this reason, an in-depth exploration of viral mechanisms is critical to a robust understanding of SARS-CoV-2 and, potentially, future emergent human CoVs (HCoVs).

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • MacLean, Adam LUniversity of Southern California (author)
  • Lee, Alexandra JUniversity of Pennsylvania (author)
  • Lordan, RonanUniversity of Pennsylvania (author)
  • Ray, SandipanIndian Institute of Technology, Hyderabad (author)
  • Bansal, VikasGerman Center for Neurodegenerative Diseases (DZNE), Tubingen (author)
  • Skelly, Ashwin NUniversity of Pennsylvania (author)
  • Sell, ElizabethUniversity of Pennsylvania (author)
  • Dziak, John JPennsylvania State University (author)
  • Shinholster, LamonicaMercer University at Macon (author)
  • D'Agostino McGowan, LucyWake Forest University (author)
  • Ben Guebila, MarouenHarvard T.H. Chan School of Public Health (author)
  • Wellhausen, NilsUniversity of Pennsylvania (author)
  • Knyazev, SergeyGeorgia State University (author)
  • Boca, Simina MGeorgetown University Medical Center (author)
  • Capone, StephenSt. George's University School of Medicine (author)
  • Qi, YanjunUniversity of Virginia (author)
  • Park, YoSonUniversity of Pennsylvania (author)
  • Mai, DavidUniversity of Pennsylvania (author)
  • Sun, YuchenUniversity of Virginia (author)
  • Boerckel, Joel DUniversity of Pennsylvania (author)
  • Brueffer, ChristianLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-csb (author)
  • Byrd, James BrianUniversity of Michigan (author)
  • Kamil, Jeremy PLouisiana State University Health Sciences Center, Shreveport (author)
  • Wang, JinhuiUniversity of Pennsylvania (author)
  • Velazquez, Ryan (author)
  • Szeto, Gregory LAllen Institute Immunology (author)
  • Barton, John PUniversity of California, Riverside (author)
  • Goel, Rishi RajUniversity of Pennsylvania (author)
  • Mangul, SergheiUniversity of Southern California (author)
  • Lubiana, TiagoUniversity of São Paulo (author)
  • Gitter, AnthonyUniversity of Wisconsin-Madison (author)
  • Greene, Casey SUniversity of Colorado School of Medicine,University of Pennsylvania (author)
  • University of Colorado School of MedicineUniversity of Pennsylvania (creator_code:org_t)
  • COVID-19 Review Consortium

Related titles

  • In:mSystems6:52379-5077

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