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  • Anand, AseemLund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups,Memorial Sloan-Kettering Cancer Center (author)

Automated Bone Scan Index to Optimize Prostate Cancer Working Group Radiographic Progression Criteria for Men With Metastatic Castration-Resistant Prostate Cancer

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier BV,2022

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:38a2bf03-e2c3-4971-8e55-493808a01ab4
  • https://lup.lub.lu.se/record/38a2bf03-e2c3-4971-8e55-493808a01ab4URI
  • https://doi.org/10.1016/j.clgc.2022.02.002DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Introduction: Radiographic progression-free survival (rPFS) by Prostate Cancer Working Group (PCWG) criteria is a radiographic endpoint. The automated bone scan index (aBSI) quantifies osseous disease burden on bone scintigraphy as a percentage of total skeletal weight. Using the aBSI, we sought to quantify increase in tumor burden represented by PCWG progression criteria, and to determine the interval increase that best associates with overall survival (OS). Patient and Methods: Retrospective analysis of trials using androgen receptor axis–targeted drugs for metastatic castration resistant prostate cancer patients (mCRPC). aBSI increase in bone disease was assessed from baseline scan to time-to-progression (per PCWG criteria). Threshold for time to aBSI increase were explored and the association between each time-to-threshold and OS was computed. Results: A total of 169 mCPRC patients had bone scans available for aBSI analysis. Of these, 90 (53%) had progression in bone meeting PCWG criteria. Total aBSI increase in patients meeting PCWG criteria was 1.22 (interquartile range [IQR]: 0.65-2.49), with a median relative increase of 109% (IQR: 40%-377%). Median aBSI at baseline was 3.1 (IQR: 1.3-7.1). The best association between OS and time-to-progression occurred with an absolute increase in aBSI equal to 0.6 (Kendall's tau 0.52). Conclusion: An absolute increase of 0.6 or more in aBSI from the first follow-up scan results in the highest association with OS in patients with mCRPC. The rPFS by PCWG, identified progression at nearly twice this tumor burden, suggesting that aBSI may be used to further develop the PCWG criteria without degrading its association with OS.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Heller, GlennMemorial Sloan-Kettering Cancer Center (author)
  • Fox, JosephMemorial Sloan-Kettering Cancer Center (author)
  • Danila, Daniel C.Memorial Sloan-Kettering Cancer Center,Weill Cornell Medical College (author)
  • Bjartell, AndersLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)kir-abj (author)
  • Edenbrandt, LarsLund University,Lunds universitet,Nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Nuclear medicine, Malmö,Lund University Research Groups,Skåne University Hospital,Sahlgrenska University Hospital(Swepub:lu)klfy-led (author)
  • Larson, Steven M.Weill Cornell Medical College,Memorial Sloan-Kettering Cancer Center (author)
  • Scher, Howard I.Weill Cornell Medical College,Memorial Sloan-Kettering Cancer Center (author)
  • Morris, Michael J.Memorial Sloan-Kettering Cancer Center,Weill Cornell Medical College (author)
  • Urologisk cancerforskning, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Clinical Genitourinary Cancer: Elsevier BV20:3, s. 270-2771558-7673

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