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Vaginal and urine s...
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Asciutto, Katrin ChristineLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
(author)
Vaginal and urine self-sampling compared to cervical sampling for HPV-testing with the cobas 4800 HPV test
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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Anticancer Research USA Inc.2017
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5 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:39678402-e031-4552-bbfc-cf8bbcd2b578
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https://lup.lub.lu.se/record/39678402-e031-4552-bbfc-cf8bbcd2b578URI
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https://doi.org/10.21873/anticanres.11807DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background/Aim: To compare human papillomavirus (HPV) DNA detection in self-collected vaginal and urine samples with clinician-taken cervical samples in relation to histology. Materials and Methods: Self-collected vaginal, urine and clinician-taken cervical samples were analyzed from 218 women with the Cobas 4800 HPV test (Roche Molecular Diagnostics). Results: The sensitivity for detection of HPV in the vaginal self-sampling test was 96.4% and in urine was 83.9% relative to detection by clinician-taken cervical sample. The vaginal self-sampling and the clinician-taken HPV tests had the same sensitivity of 92.8% (95% confidence interval=86.3-96.8%) and specificity for detection of high-grade squamous intraepithelial lesion (HSIL) and adenocarcinoma in situ (AIS). Detection in urine samples had a sensitivity of 76.3% (95% confidence interval=67.9-84.2%) for HSIL/AIS. Conclusion: The Cobas 4800 HPV test detects high-grade pre-cancerous cervical lesions in self-collected vaginal samples with the same high sensitivity as in clinician-taken cervical samples.
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Henningsson, Anna JRyhov County Hospital, Jönköping
(author)
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Borgfeldt, HenrikLund University
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Darlin, LottenLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-lde
(author)
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Borgfeldt, ChristerLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)gyn-cbo
(author)
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Obstetrik och gynekologi, LundSektion V
(creator_code:org_t)
Related titles
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In:Anticancer research: Anticancer Research USA Inc.37:8, s. 4183-41870250-70051791-7530
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