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Association of four...
Association of four DNA polymorphisms with acute rejection after kidney transplantation
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Grinyo, Josep (author)
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Vanrenterghem, Yves (author)
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Nashan, Bjoern (author)
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Vincenti, Flavio (author)
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- Ekberg, Henrik (author)
- Lund University,Lunds universitet,Enheten för forskning kring njurfunktion och njursjukdom,Kirurgi,Forskargrupper vid Lunds universitet,Renal Research Unit,Surgery,Lund University Research Groups
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Lindpaintner, Klaus (author)
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Rashford, Michelle (author)
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Nasmyth-Miller, Clare (author)
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Voulgari, Athina (author)
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Spleiss, Olivia (author)
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Truman, Matthew (author)
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Essioux, Laurent (author)
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(creator_code:org_t)
- Frontiers Media SA, 2008
- 2008
- English.
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In: Transplant International. - : Frontiers Media SA. - 1432-2277 .- 0934-0874. ; 21:9, s. 879-891
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Renal transplant outcomes exhibit large inter-individual variability, possibly on account of genetic variation in immune-response mediators and genes influencing the pharmacodynamics/pharmacokinetics of immunosuppressants. We examined 21 polymorphisms from 10 genes in 237 de novo renal transplant recipients participating in an open-label, multicenter study [Cyclosporine Avoidance Eliminates Serious Adverse Renal-toxicity (CAESAR)] investigating renal function and biopsy-proven acute rejection (BPAR) with different cyclosporine A regimens and mycophenolate mofetil. Genes were selected for their immune response and pharmacodynamic/pharmacokinetic relevance and were tested for association with BPAR. Four polymorphisms were significantly associated with BPAR. The ABCB1 2677T allele tripled the odds of developing BPAR (OR: 3.16, 95% CI [1.50-6.67]; P = 0.003), as did the presence of at least one IMPDH2 3757C allele (OR: 3.39, 95% CI [1.42-8.09]; P = 0.006). BPAR was almost fivefold more likely in patients homozygous for IL-10 -592A (OR: 4.71, 95% CI [1.52-14.55]; P = 0.007) and twice as likely in patients with at least one A allele of TNF-alpha G-308A (OR: 2.18, 95% CI [1.08-4.41]; P = 0.029). There were no statistically significant interactions between polymorphisms, or the different treatment regimens. Variation in genes of immune response and pharmacodynamic/pharmacokinetic relevance may be important in understanding acute rejection after renal transplant.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- single nucleotide polymorphism
- acute rejection
- kidney transplantation
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Grinyo, Josep
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Vanrenterghem, Y ...
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Nashan, Bjoern
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Vincenti, Flavio
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Ekberg, Henrik
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Lindpaintner, Kl ...
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show more...
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Rashford, Michel ...
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Nasmyth-Miller, ...
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Voulgari, Athina
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Spleiss, Olivia
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Truman, Matthew
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Essioux, Laurent
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Transplant Inter ...
- By the university
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Lund University