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Association of four...
Association of four DNA polymorphisms with acute rejection after kidney transplantation
- Article/chapterEnglish2008
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LIBRIS-ID:oai:lup.lub.lu.se:397dfefb-233d-4281-98d3-dc5d7845ab51
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https://lup.lub.lu.se/record/1252116URI
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https://doi.org/10.1111/j.1432-2277.2008.00679.xDOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Renal transplant outcomes exhibit large inter-individual variability, possibly on account of genetic variation in immune-response mediators and genes influencing the pharmacodynamics/pharmacokinetics of immunosuppressants. We examined 21 polymorphisms from 10 genes in 237 de novo renal transplant recipients participating in an open-label, multicenter study [Cyclosporine Avoidance Eliminates Serious Adverse Renal-toxicity (CAESAR)] investigating renal function and biopsy-proven acute rejection (BPAR) with different cyclosporine A regimens and mycophenolate mofetil. Genes were selected for their immune response and pharmacodynamic/pharmacokinetic relevance and were tested for association with BPAR. Four polymorphisms were significantly associated with BPAR. The ABCB1 2677T allele tripled the odds of developing BPAR (OR: 3.16, 95% CI [1.50-6.67]; P = 0.003), as did the presence of at least one IMPDH2 3757C allele (OR: 3.39, 95% CI [1.42-8.09]; P = 0.006). BPAR was almost fivefold more likely in patients homozygous for IL-10 -592A (OR: 4.71, 95% CI [1.52-14.55]; P = 0.007) and twice as likely in patients with at least one A allele of TNF-alpha G-308A (OR: 2.18, 95% CI [1.08-4.41]; P = 0.029). There were no statistically significant interactions between polymorphisms, or the different treatment regimens. Variation in genes of immune response and pharmacodynamic/pharmacokinetic relevance may be important in understanding acute rejection after renal transplant.
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Vanrenterghem, Yves
(author)
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Nashan, Bjoern
(author)
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Vincenti, Flavio
(author)
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Ekberg, HenrikLund University,Lunds universitet,Enheten för forskning kring njurfunktion och njursjukdom,Kirurgi,Forskargrupper vid Lunds universitet,Renal Research Unit,Surgery,Lund University Research Groups(Swepub:lu)kir-hek
(author)
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Lindpaintner, Klaus
(author)
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Rashford, Michelle
(author)
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Nasmyth-Miller, Clare
(author)
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Voulgari, Athina
(author)
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Spleiss, Olivia
(author)
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Truman, Matthew
(author)
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Essioux, Laurent
(author)
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Enheten för forskning kring njurfunktion och njursjukdomKirurgi
(creator_code:org_t)
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In:Transplant International: Frontiers Media SA21:9, s. 879-8911432-22770934-0874
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Grinyo, Josep
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Vanrenterghem, Y ...
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Nashan, Bjoern
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Vincenti, Flavio
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Ekberg, Henrik
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Lindpaintner, Kl ...
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Rashford, Michel ...
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Voulgari, Athina
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Spleiss, Olivia
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Truman, Matthew
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Essioux, Laurent
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- MEDICAL AND HEALTH SCIENCES
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Transplant Inter ...
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Lund University