Search: WFRF:(Kristensen Anders) >
Impaired Antibody R...
Impaired Antibody Response Is Associated with Histone-Release, Organ Dysfunction and Mortality in Critically Ill COVID-19 Patients
-
- Lagedal, Rickard (author)
- Uppsala universitet,Anestesiologi och intensivvård
-
- Eriksson, Oskar, 1984- (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- Sörman, Anna, 1981- (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
show more...
-
- Huckriede, Joram B. (author)
- Maastricht Univ, Netherlands,Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6211 LK Maastricht, The Netherlands.
-
- Kristensen, Bjarne (author)
- Thermo Fisher Sci, Denmark,Thermo Fisher Scientific, 3450 Allerod, Denmark.
-
- Franzén, Stephanie (author)
- Uppsala universitet,Anestesiologi och intensivvård
-
- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
-
- Bergqvist, Anders (author)
- Uppsala universitet,Klinisk mikrobiologi
-
- Alving, Kjell, 1959- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
-
- Forslund, Anders, 1961- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6211 LK Maastricht, The Netherlands.
-
- Persson, Barbro (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- Nilsson Ekdahl, Kristina (author)
- Uppsala universitet,Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Uppsala University, Sweden,Linnaeus Ctr Biomat Chem, BMC,Institutionen för immunologi, genetik och patologi
-
- Garcia de Frutos, Pablo (author)
- Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS and CIBERCV, 08036 Barcelona, Spain.
-
- Nilsson, Bo (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- Nicolaes, Gerry A. F. (author)
- Maastricht Univ, Netherlands
-
- Lipcsey, Miklós (author)
- Uppsala universitet,Hedenstiernalaboratoriet
-
- Hultström, Michael, 1978- (author)
- Uppsala universitet,Anestesiologi och intensivvård,Unit for Integrative Physiology, Department of Medical Cell Biology, Uppsala University, 752 36 Uppsala, Sweden.
-
- Frithiof, Robert (author)
- Uppsala universitet,Anestesiologi och intensivvård
-
show less...
-
(creator_code:org_t)
- 2022-06-14
- 2022
- English.
-
In: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 11:12
- Related links:
-
https://doi.org/10.3...
-
show more...
-
https://lnu.diva-por... (primary) (Raw object)
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Purpose: the pathophysiologic mechanisms explaining differences in clinical outcomes following COVID-19 are not completely described. This study aims to investigate antibody responses in critically ill patients with COVID-19 in relation to inflammation, organ failure and 30-day survival. Methods: All patients with PCR-verified COVID-19 and gave consent, and who were admitted to a tertiary Intensive care unit (ICU) in Sweden during March-September 2020 were included. Demography, repeated blood samples and measures of organ function were collected. Analyses of anti-SARS-CoV-2 antibodies (IgM, IgA and IgG) in plasma were performed and correlated to patient outcome and biomarkers of inflammation and organ failure. Results: A total of 115 patients (median age 62 years, 77% male) were included prospectively. All patients developed severe respiratory dysfunction, and 59% were treated with invasive ventilation. Thirty-day mortality was 22.6% for all included patients. Patients negative for any anti-SARS-CoV-2 antibody in plasma during ICU admission had higher 30-day mortality compared to patients positive for antibodies. Patients positive for IgM had more ICU-, ventilator-, renal replacement therapy- and vasoactive medication-free days. IgA antibody concentrations correlated negatively with both SAPS3 and maximal SOFA-score and IgM-levels correlated negatively with SAPS3. Patients with antibody levels below the detection limit had higher plasma levels of extracellular histones on day 1 and elevated levels of kidney and cardiac biomarkers, but showed no signs of increased inflammation, complement activation or cytokine release. After adjusting for age, positive IgM and IgG antibodies were still associated with increased 30-day survival, with odds ratio (OR) 7.1 (1.5-34.4) and 4.2 (1.1-15.7), respectively. Conclusion: In patients with severe COVID-19 requiring intensive care, a poor antibody response is associated with organ failure, systemic histone release and increased 30-day mortality.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- COVID-19
- SARS-CoV-2
- critical care
- antibody response
- NET
- histones
- Immunologi
- Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lagedal, Rickard
-
Eriksson, Oskar, ...
-
Sörman, Anna, 19 ...
-
Huckriede, Joram ...
-
Kristensen, Bjar ...
-
Franzén, Stephan ...
-
show more...
-
Larsson, Anders
-
Bergqvist, Ander ...
-
Alving, Kjell, 1 ...
-
Forslund, Anders ...
-
Persson, Barbro
-
Nilsson Ekdahl, ...
-
Garcia de Frutos ...
-
Nilsson, Bo
-
Nicolaes, Gerry ...
-
Lipcsey, Miklós
-
Hultström, Micha ...
-
Frithiof, Robert
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Immunology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Anesthesiology a ...
- Articles in the publication
-
Journal of Clini ...
- By the university
-
Linnaeus University
-
Uppsala University