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  • Watt, F. E.University of Oxford (author)

Towards prevention of post-traumatic osteoarthritis : report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • Elsevier BV,2019

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:3ae3ad11-1e91-43ad-8759-f5925e310365
  • https://lup.lub.lu.se/record/3ae3ad11-1e91-43ad-8759-f5925e310365URI
  • https://doi.org/10.1016/j.joca.2018.08.001DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objective: There are few guidelines for clinical trials of interventions for prevention of post-traumatic osteoarthritis (PTOA), reflecting challenges in this area. An international multi-disciplinary expert group including patients was convened to generate points to consider for the design and conduct of interventional studies following acute knee injury. Design: An evidence review on acute knee injury interventional studies to prevent PTOA was presented to the group, alongside overviews of challenges in this area, including potential targets, biomarkers and imaging. Working groups considered pre-identified key areas: eligibility criteria and outcomes, biomarkers, injury definition and intervention timing including multi-modality interventions. Consensus agreement within the group on points to consider was generated and is reported here after iterative review by all contributors. Results: The evidence review identified 37 studies. Study duration and outcomes varied widely and 70% examined surgical interventions. Considerations were grouped into three areas: justification of inclusion criteria including the classification of injury and participant age (as people over 35 may have pre-existing OA); careful consideration in the selection and timing of outcomes or biomarkers; definition of the intervention(s)/comparator(s) and the appropriate time-window for intervention (considerations may be particular to intervention type). Areas for further research included demonstrating the utility of patient-reported outcomes, biomarkers and imaging outcomes from ancillary/cohort studies in this area, and development of surrogate clinical trial endpoints that shorten the duration of clinical trials and are acceptable to regulatory agencies. Conclusions: These considerations represent the first international consensus on the conduct of interventional studies following acute knee joint trauma.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Corp, N.Keele University (author)
  • Kingsbury, S. R.University of Leeds (author)
  • Frobell, R.Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)sjuk-rfr (author)
  • Englund, M.Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)ort-med (author)
  • Felson, D. T.University of Manchester,Boston University (author)
  • Levesque, M.AbbVie Inc. (author)
  • Majumdar, S.University of Texas Health Science Centre (author)
  • Wilson, C.Cardiff University (author)
  • Beard, D. J.University of Oxford (author)
  • Lohmander, L. S.Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)ort-slo (author)
  • Kraus, V. B.Duke University (author)
  • Roemer, F.Boston University,Friedrich-Alexander University Erlangen-Nürnberg(Swepub:lu)med-fkr (author)
  • Conaghan, P. G.University of Leeds (author)
  • Mason, D. J.Cardiff University (author)
  • Adams, J.University of Southampton (author)
  • Blank, M. (author)
  • Batt, M.University of Nottingham (author)
  • Biggs, P.Cardiff University (author)
  • Busse-Morris, M.Cardiff University (author)
  • Button, K.Cardiff University (author)
  • Calder, J. (author)
  • Cook, J.University of Oxford (author)
  • Edwards, C.University of Southampton (author)
  • Fisheleva, E. (author)
  • Hamilton, D. F.University of Edinburgh (author)
  • Harrison, H. (author)
  • Holt, C.Cardiff University (author)
  • Jones, M. (author)
  • Jones, R.University of Salford (author)
  • Kluzek, S.University of Oxford (author)
  • Knight, T. (author)
  • Nuki, G.University of Edinburgh (author)
  • Parekh, S.University College London (author)
  • Peat, G.Keele University (author)
  • Pothet, C. (author)
  • Rainer, T.Cardiff University (author)
  • Robinson, N.London South Bank University (author)
  • Sawle, L.Cardiff University (author)
  • Vincent, T. (author)
  • Williams, A. (author)
  • Wise, E. (author)
  • Zhang, W.University of Nottingham (author)
  • Bierma-Zeinstra, S.Erasmus University Medical Center (author)
  • University of OxfordKeele University (creator_code:org_t)

Related titles

  • In:Osteoarthritis and Cartilage: Elsevier BV27:1, s. 23-331063-4584

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