id:"swepub:oai:lup.lub.lu.se:3b064c5c-9848-46ab-8d5d-506c4ef5056e"
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- Henrik, GrelzLund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Skåne University Hospital (författare)
Tapering of prescribed opioids in patients with long-term non-malignant pain (TOPIO)-efficacy and effects on pain, pain cognitions, and quality of life : a study protocol for a randomized controlled clinical trial with a 12-month follow-up
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
- 2021-07-28
- Springer Science and Business Media LLC,2021
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:3b064c5c-9848-46ab-8d5d-506c4ef5056e
- https://lup.lub.lu.se/record/3b064c5c-9848-46ab-8d5d-506c4ef5056eURI
- https://doi.org/10.1186/s13063-021-05449-5DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- BACKGROUND: Opioids are still widely prescribed to long-term pain patients although they are no longer recommended for long-term treatments due to poor evidence for long-term efficacy, risks of serious side effects, and the possibility of inducing opioid hyperalgesia. In a Cochrane study from 2017, the authors identified an urgent need for more randomized controlled trials investigating the efficiency and effects of opioid tapering. The study aimed to assess (1) the efficiency of a structured intervention in causing stable reductions of opioid consumption in a population with long-term non-malignant pain and (2) effects on pain, pain cognitions, physical and mental health, quality of life, and functioning in response to opioid tapering.METHODS: The study is a randomized controlled trial. The sample size was set to a total of 140 individuals after estimation of power and dropout. Participants will be recruited from a population with long-term non-malignant pain who will be randomly allocated to (1) the start of tapering immediately or (2) the control group who return to usual care and will commence tapering of opioids 4 months later. A 12-month follow-up is included. When all follow-ups are closed, data from the Swedish drug register of the National Board of Health and Welfare will be collected and individual mean daily opioid dose in morphine equivalents will be calculated at three time points: baseline, 4 months, and 12 months after the start of the intervention. At the same time points, participants fill out the following questionnaires: Numeric Pain Rating Scale (NPRS), Tampa Scale of Kinesiophobia (TSK), Pain Catastrophizing Scale (PCS), Chronic Pain Acceptance Questionnaire (CPAQ-8), Hospital Anxiety and Depression Scale (HADS), and RAND-36. At baseline and follow-up, a clinical assessment of opioid use disorder is performed.DISCUSSION: A better understanding of the efficiency and effects of opioid tapering could possibly facilitate attempts to taper opioid treatments, which might prove beneficial for both the individual and society.TRIAL REGISTRATION: ClinicalTrials.gov NCT03485430 . Retrospectively registered on 26 March 2018, first release date. "Tapering of Long-term Opioid Therapy in Chronic Pain Population. RCT with 12 Months Follow up (TOPIO)." First patient in trial 22 March 2018.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Annan klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Other Clinical Medicine hsv//eng
- Analgesics, Opioid/adverse effects
- Chronic Pain/diagnosis
- Cognition
- Follow-Up Studies
- Humans
- Quality of Life
- Randomized Controlled Trials as Topic
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Patrik, MidlövLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Family Medicine and Community Medicine,Lund University Research Groups(Swepub:lu)klin-pmi (författare)
- Anders, HåkanssonLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för klinisk beroendeforskning,Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical addiction research unit,Lund University Research Groups(Swepub:lu)med-adh (författare)
- Ulf, JakobssonLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)cvv-uja (författare)
- Marcelo, Rivano FischerLund University,Lunds universitet,Rehabiliteringsmedicin,Forskargrupper vid Lunds universitet,Rehabilitation medicine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-mor (författare)
- Åsa, RingqvistLund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-aar (författare)
- Allmänmedicin och samhällsmedicinForskargrupper vid Lunds universitet (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Trials: Springer Science and Business Media LLC221745-6215
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