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  • Mühlemann, BarbaraUniversity of Cambridge,German Center for Infection Research (DZIF),Charité - University Medicine Berlin (author)

Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • American Association for the Advancement of Science (AAAS),2020

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:3b092008-1b5a-44c9-a943-e0f72ed79464
  • https://lup.lub.lu.se/record/3b092008-1b5a-44c9-a943-e0f72ed79464URI
  • https://doi.org/10.1126/science.aaw8977DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Smallpox, one of the most devastating human diseases, killed between 300 million and 500 million people in the 20th century alone. We recovered viral sequences from 13 northern European individuals, including 11 dated to ~600-1050 CE, overlapping the Viking Age, and reconstructed near-complete variola virus genomes for four of them. The samples predate the earliest confirmed smallpox cases by ~1000 years, and the sequences reveal a now-extinct sister clade of the modern variola viruses that were in circulation before the eradication of smallpox. We date the most recent common ancestor of variola virus to ~1700 years ago. Distinct patterns of gene inactivation in the four near-complete sequences show that different evolutionary paths of genotypic host adaptation resulted in variola viruses that circulated widely among humans.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Vinner, LasseUniversity of Copenhagen (author)
  • Margaryan, AshotInstitute of Molecular Biology, National Academy of Sciences of Armenia,University of Copenhagen (author)
  • Wilhelmson, HeleneLund University,Lunds universitet,Gravarkeologiska forskargruppen – Död, begravning och social identitet,Forskargrupper vid Lunds universitet,Arkeologi,Institutionen för arkeologi och antikens historia,Institutioner,Humanistiska och teologiska fakulteterna,The Burial Archaeological Research Group – Death, Burial, and Social Identity,Lund University Research Groups,Archaeology,Department of Archaeology and Ancient History,Departments,Joint Faculties of Humanities and Theology(Swepub:lu)ark-hwo (author)
  • de la Fuente Castro, ConstanzaUniversity of Chicago (author)
  • Allentoft, Morten E.Curtin University,University of Copenhagen (author)
  • de Barros Damgaard, PeterUniversity of Copenhagen (author)
  • Hansen, Anders JohannesUniversity of Copenhagen (author)
  • Holtsmark Nielsen, SofieUniversity of Copenhagen (author)
  • Strand, Lisa MariannNorwegian University of Science and Technology (author)
  • Bill, JanUniversity of Oslo (author)
  • Buzhilova, AlexandraLomonosov Moscow State University (author)
  • Pushkina, TamaraLomonosov Moscow State University (author)
  • Falys, CeriThames Valley Archaeological Services (author)
  • Khartanovich, ValeriPeter the Great Museum of Anthropology and Ethnography (author)
  • Moiseyev, VyacheslavPeter the Great Museum of Anthropology and Ethnography (author)
  • Jørkov, Marie Louise SchjellerupUniversity of Copenhagen (author)
  • Østergaard Sørensen, PalleRoskilde Museum,Frederikssund Museum (author)
  • Magnusson, YvonneMalmö museer (author)
  • Gustin, IngridLund University,Lunds universitet,Gravarkeologiska forskargruppen – Död, begravning och social identitet,Forskargrupper vid Lunds universitet,Historisk arkeologi,Institutionen för arkeologi och antikens historia,Institutioner,Humanistiska och teologiska fakulteterna,The Burial Archaeological Research Group – Death, Burial, and Social Identity,Lund University Research Groups,Historical Archaeology,Department of Archaeology and Ancient History,Departments,Joint Faculties of Humanities and Theology(Swepub:lu)ark-igu (author)
  • Schroeder, HannesUniversity of Copenhagen (author)
  • Sutter, GerdLudwig-Maximilian University of Munich,German Center for Infection Research (DZIF) (author)
  • Smith, Geoffrey L.University of Cambridge (author)
  • Drosten, ChristianCharité - University Medicine Berlin,German Center for Infection Research (DZIF) (author)
  • Fouchier, Ron A.M.Erasmus University Medical Center (author)
  • Smith, Derek J.University of Cambridge (author)
  • Willerslev, EskeUniversity of Cambridge,University of Southern Denmark,Wellcome Trust Sanger Institute,University of Copenhagen (author)
  • Jones, Terry C.Charité - University Medicine Berlin,German Center for Infection Research (DZIF),University of Cambridge (author)
  • Sikora, MartinUniversity of Copenhagen (author)
  • University of CambridgeGerman Center for Infection Research (DZIF) (creator_code:org_t)

Related titles

  • In:Science (New York, N.Y.): American Association for the Advancement of Science (AAAS)369:65021095-92030036-8075

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