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High relapse rate o...
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Kozlowski, Piotr,1969-Region Örebro län,Hematology Section, Department of Medicine, Örebro University Hospital, Örebro, Sweden
(author)
High relapse rate of T cell acute lymphoblastic leukemia in adults treated with Hyper-CVAD chemotherapy in Sweden
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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LIBRIS-ID:oai:lup.lub.lu.se:3b5a8885-dd91-4159-a389-0c85ce3dfaec
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https://lup.lub.lu.se/record/4438856URI
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https://doi.org/10.1111/ejh.12269DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-48486URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:128686917URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88943URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-224711URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-106674URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background Hyper-CVAD is widely used to treat acute lymphoblastic leukemia (ALL) and aggressive lymphomas. This multicenter, population-based study assessed the efficacy of Hyper-CVAD as first-line therapy in patients with T-cell ALL (T-ALL). Patients and methods Between October 2002 and September 2006, 24 patients were diagnosed with T-ALL in Sweden; 19 were eligible for treatment with the protocol. Results The median age was 32yr (range 18-72yr). Complete remission (CR) was obtained in 17 of 19 (89%) patients, and the treatment was relatively well tolerated. Allogeneic stem cell transplantation (SCT) was recommended in high-risk disease and was performed in four patients upfront. Two- and 5-yr leukemia-free survivals (LFS) in 17 patients with CR achievement were identical, at 29% (95% confidence interval [CI]: 8-51). Two- and 5-yr overall survival (OS) in whole cohort was 63% (95% CI: 42-85) and 47% (95% CI: 26-69), respectively. The 5-yr LFS for 15 patients who did not receive allogeneic SCT upfront were 20% (95% CI: 0-40), although 14 of 15 completed the protocol (eight cycles). Relapse occurred in 2 of 4 upfront-transplanted patients and in 12 of 15 patients treated with chemotherapy alone, six of whom received allogeneic SCT in CR2. Age >= 35yr influenced OS negatively in univariate analysis (HR 5.1, 95% CI: 1.55-16.7). Conclusions Hyper-CVAD treatment resulted in a high CR rate and appeared safe, but it showed poor efficacy at preventing relapse. Therefore, this treatment is no longer recommended for adults with T-ALL in Sweden.
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Åström, Maria,1959-Region Örebro län,Hematology Section, Department of Medicine, Örebro University Hospital, Örebro, Sweden(Swepub:oru)mram
(author)
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Ahlberg, LuciaÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Hematologiska kliniken US(Swepub:liu)lucah64
(author)
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Bernell, PerKarolinska University Hospital, Stockholm, Sweden
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Hulegardh, ErikDepartment of Hematology and Coagulation, Sahlgrenska University, Göteborg, Sweden
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Hägglund, HansUppsala universitet,Karolinska Institutet,Hematologi,Karolinska University Hospital, Sweden(Swepub:uu)hanha689
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Karlsson, KarinLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Department of Hematology, Skåne University Hospital, Lund, Sweden(Swepub:lu)stem-kka
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Markuszewska-Kuczymska, AlicjaUmeå universitet,Onkologi,University Hospital, Sweden(Swepub:umu)alma0043
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Tomaszewska-Toporska, BeataDepartment of Hematology, Skåne University Hospital, Lund, Sweden
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Smedmyr, BengtUppsala universitet,Hematologi,Uppsala University, Sweden(Swepub:uu)besme236
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Amini, Rose-MarieUppsala universitet,Molekylär och morfologisk patologi,Uppsala University, Sweden(Swepub:uu)roseamin
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Hallböök, HeleneUppsala universitet,Hematologi,Uppsala University, Sweden(Swepub:uu)helehall
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Region Örebro länHematology Section, Department of Medicine, Örebro University Hospital, Örebro, Sweden
(creator_code:org_t)
Related titles
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In:European Journal of Haematology: Wiley92:5, s. 377-3811600-06090902-4441
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Kozlowski, Piotr ...
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Åström, Maria, 1 ...
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Ahlberg, Lucia
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Bernell, Per
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Hulegardh, Erik
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Hägglund, Hans
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Karlsson, Karin
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