Search: WFRF:(Andersson Malin E 1978) >
Alzheimer's disease...
Alzheimer's disease: No effect of the CDK5 gene on CSF biomarkers, neuropathology or disease risk
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- Sjölander, Annica, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institutionen för vårdvetenskap och hälsa,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Institute of Health and Care Sciences
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- Andersson, Malin E, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
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- Minthon, Lennart (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Bogdanovic, Nenad (author)
- Karolinska Institutet
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- Spandidos Publications, 2009
- 2009
- English.
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In: Molecular Medicine Reports. - : Spandidos Publications. - 1791-3004 .- 1791-2997. ; 2:6, s. 989-992
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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https://gup.ub.gu.se...
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http://kipublication...
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Abstract
Subject headings
Close
- Cyclin-dependent kinase 5 (cdk5) has been identified as one of the kinases that phosphorylates tau at several Alzheimer's disease (AD)-associated sites. Cdk5 is predominantly expressed in neurons, and has higher activity in AD brains than in non-demented brains. To investigate the effect of the CDK5 gene on AD, we analyzed an SNP of the CDK5 gene (rs2069456) in 347 patients with AD and in 157 controls. CDK5 genetic data was investigated in subgroups in relation to biochemical and neuropathological markers for AD. We found no significant differences in genotype or allele distributions between AD patients and controls. None of the CDK5 gene variants influenced biomarkers for AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- cerebrospinal fluid
- apolipoprotein E
- beta-amyloid
- tau
- Alzheimer's disease
- cyclin-dependent kinase 5
- biomarkers
- plaque
- tangle
Publication and Content Type
- art (subject category)
- ref (subject category)
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