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Common variants at ...
Common variants at 30 loci contribute to polygenic dyslipidemia
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Kathiresan, Sekar (author)
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Willer, Cristen J. (author)
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Peloso, Gina M. (author)
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show more...
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Demissie, Serkalem (author)
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Musunuru, Kiran (author)
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Schadt, Eric E. (author)
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Kaplan, Lee (author)
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Bennett, Derrick (author)
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Li, Yun (author)
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Tanaka, Toshiko (author)
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Voight, Benjamin F. (author)
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Bonnycastle, Lori L. (author)
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Jackson, Anne U. (author)
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Crawford, Gabriel (author)
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Surti, Aarti (author)
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Guiducci, Candace (author)
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Burtt, Noel P. (author)
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Parish, Sarah (author)
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Clarke, Robert (author)
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Zelenika, Diana (author)
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Kubalanza, Kari A. (author)
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Morken, Mario A. (author)
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Scott, Laura J. (author)
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Stringham, Heather M. (author)
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Galan, Pilar (author)
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Swift, Amy J. (author)
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Kuusisto, Johanna (author)
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Bergman, Richard N. (author)
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Sundvall, Jouko (author)
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Laakso, Markku (author)
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Ferrucci, Luigi (author)
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Scheet, Paul (author)
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Sanna, Serena (author)
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Uda, Manuela (author)
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Yang, Qiong (author)
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Lunetta, Kathryn L. (author)
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Dupuis, Josee (author)
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de Bakker, Paul I. W. (author)
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O'Donnell, Christopher J. (author)
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Chambers, John C. (author)
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Kooner, Jaspal S. (author)
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Hercberg, Serge (author)
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Meneton, Pierre (author)
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Lakatta, Edward G. (author)
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Scuteri, Angelo (author)
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Schlessinger, David (author)
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Tuomilehto, Jaakko (author)
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Collins, Francis S. (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Altshuler, David (author)
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Collins, Rory (author)
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Lathrop, G. Mark (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Salomaa, Veikko (author)
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Peltonen, Leena (author)
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Ordovas, Jose M. (author)
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Boehnke, Michael (author)
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Abecasis, Goncalo R. (author)
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Mohlke, Karen L. (author)
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Cupples, L. Adrienne (author)
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(creator_code:org_t)
- 2008-12-07
- 2009
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:1, s. 56-65
- Related links:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to 20,623 individuals. We identified 30 distinct loci associated with lipoprotein concentrations (each with P < 5 x 10(-8)), including 11 loci that reached genome-wide significance for the first time. The 11 newly defined loci include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP. The proportion of individuals exceeding clinical cut points for high LDL cholesterol, low HDL cholesterol and high triglycerides varied according to an allelic dosage score (P < 10(-15) for each trend). These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Kathiresan, Seka ...
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Willer, Cristen ...
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Peloso, Gina M.
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Demissie, Serkal ...
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Musunuru, Kiran
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Schadt, Eric E.
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show more...
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Kaplan, Lee
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Bennett, Derrick
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Li, Yun
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Tanaka, Toshiko
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Voight, Benjamin ...
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Bonnycastle, Lor ...
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Jackson, Anne U.
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Crawford, Gabrie ...
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Surti, Aarti
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Guiducci, Candac ...
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Burtt, Noel P.
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Parish, Sarah
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Clarke, Robert
-
Zelenika, Diana
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Kubalanza, Kari ...
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Morken, Mario A.
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Scott, Laura J.
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Stringham, Heath ...
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Galan, Pilar
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Swift, Amy J.
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Kuusisto, Johann ...
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Bergman, Richard ...
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Sundvall, Jouko
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Laakso, Markku
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Ferrucci, Luigi
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Scheet, Paul
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Sanna, Serena
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Uda, Manuela
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Yang, Qiong
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Lunetta, Kathryn ...
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Dupuis, Josee
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de Bakker, Paul ...
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O'Donnell, Chris ...
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Chambers, John C ...
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Kooner, Jaspal S ...
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Hercberg, Serge
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Meneton, Pierre
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Lakatta, Edward ...
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Scuteri, Angelo
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Schlessinger, Da ...
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Tuomilehto, Jaak ...
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Collins, Francis ...
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Groop, Leif
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Altshuler, David
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Collins, Rory
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Lathrop, G. Mark
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Melander, Olle
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Salomaa, Veikko
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Peltonen, Leena
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Orho-Melander, M ...
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Ordovas, Jose M.
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Boehnke, Michael
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Abecasis, Goncal ...
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Mohlke, Karen L.
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Cupples, L. Adri ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Nature Genetics
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Lund University