Common variants at 30 loci contribute to polygenic dyslipidemia

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MARC

Kathiresan, Sekar (author)

Common variants at 30 loci contribute to polygenic dyslipidemia

Article/chapterEnglish2009

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2008-12-07
Springer Science and Business Media LLC,2009

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LIBRIS-ID:oai:lup.lub.lu.se:3bda50e8-bbd1-4784-a049-cf6d1364419b
https://lup.lub.lu.se/record/1313138URI
https://doi.org/10.1038/ng.291DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to 20,623 individuals. We identified 30 distinct loci associated with lipoprotein concentrations (each with P < 5 x 10(-8)), including 11 loci that reached genome-wide significance for the first time. The 11 newly defined loci include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP. The proportion of individuals exceeding clinical cut points for high LDL cholesterol, low HDL cholesterol and high triglycerides varied according to an allelic dosage score (P < 10(-15) for each trend). These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia.

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Willer, Cristen J. (author)
Peloso, Gina M. (author)
Demissie, Serkalem (author)
Musunuru, Kiran (author)
Schadt, Eric E. (author)
Kaplan, Lee (author)
Bennett, Derrick (author)
Li, Yun (author)
Tanaka, Toshiko (author)
Voight, Benjamin F. (author)
Bonnycastle, Lori L. (author)
Jackson, Anne U. (author)
Crawford, Gabriel (author)
Surti, Aarti (author)
Guiducci, Candace (author)
Burtt, Noel P. (author)
Parish, Sarah (author)
Clarke, Robert (author)
Zelenika, Diana (author)
Kubalanza, Kari A. (author)
Morken, Mario A. (author)
Scott, Laura J. (author)
Stringham, Heather M. (author)
Galan, Pilar (author)
Swift, Amy J. (author)
Kuusisto, Johanna (author)
Bergman, Richard N. (author)
Sundvall, Jouko (author)
Laakso, Markku (author)
Ferrucci, Luigi (author)
Scheet, Paul (author)
Sanna, Serena (author)
Uda, Manuela (author)
Yang, Qiong (author)
Lunetta, Kathryn L. (author)
Dupuis, Josee (author)
de Bakker, Paul I. W. (author)
O'Donnell, Christopher J. (author)
Chambers, John C. (author)
Kooner, Jaspal S. (author)
Hercberg, Serge (author)
Meneton, Pierre (author)
Lakatta, Edward G. (author)
Scuteri, Angelo (author)
Schlessinger, David (author)
Tuomilehto, Jaakko (author)
Collins, Francis S. (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Altshuler, David (author)
Collins, Rory (author)
Lathrop, G. Mark (author)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
Salomaa, Veikko (author)
Peltonen, Leena (author)
Orho-Melander, MarjuLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-mor (author)
Ordovas, Jose M. (author)
Boehnke, Michael (author)
Abecasis, Goncalo R. (author)
Mohlke, Karen L. (author)
Cupples, L. Adrienne (author)
Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC41:1, s. 56-651546-17181061-4036

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By the author/editor: Kathiresan, Seka ...; Willer, Cristen ...; Peloso, Gina M.; Demissie, Serkal ...; Musunuru, Kiran; Schadt, Eric E.; show more...; Kaplan, Lee; Bennett, Derrick; Li, Yun; Tanaka, Toshiko; Voight, Benjamin ...; Bonnycastle, Lor ...; Jackson, Anne U.; Crawford, Gabrie ...; Surti, Aarti; Guiducci, Candac ...; Burtt, Noel P.; Parish, Sarah; Clarke, Robert; Zelenika, Diana; Kubalanza, Kari ...; Morken, Mario A.; Scott, Laura J.; Stringham, Heath ...; Galan, Pilar; Swift, Amy J.; Kuusisto, Johann ...; Bergman, Richard ...; Sundvall, Jouko; Laakso, Markku; Ferrucci, Luigi; Scheet, Paul; Sanna, Serena; Uda, Manuela; Yang, Qiong; Lunetta, Kathryn ...; Dupuis, Josee; de Bakker, Paul ...; O'Donnell, Chris ...; Chambers, John C ...; Kooner, Jaspal S ...; Hercberg, Serge; Meneton, Pierre; Lakatta, Edward ...; Scuteri, Angelo; Schlessinger, Da ...; Tuomilehto, Jaak ...; Collins, Francis ...; Groop, Leif; Altshuler, David; Collins, Rory; Lathrop, G. Mark; Melander, Olle; Salomaa, Veikko; Peltonen, Leena; Orho-Melander, M ...; Ordovas, Jose M.; Boehnke, Michael; Abecasis, Goncal ...; Mohlke, Karen L.; Cupples, L. Adri ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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Articles in the publication: Nature Genetics

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